The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)
Abstract
Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary DNA transcripts of viral messenger RNA's the major functional domain of the gene encoding this factor was localized to a region immediately before the env gene of the virus, a region previously thought to be noncoding. This newly identified gene consists of three exons, and its transcription into messenger RNA involves two splicing events bringing together sequences from the 5′ part (287 base pairs), middle (268 base pairs), and 3′ part (1258 base pairs) of the HTLV-III genome. A similar messenger RNA with a truncated second exon (70 base pairs) does not encode a trans -acting function. It is proposed that this second messenger RNA is the transcript of a gene (3′- orf ) located after the env gene. Messenger RNA′s were also identified for the env and gag - pol genes of HTLV-III.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043
Yoshida, M., Miyoshi, I., & Hinuma, Y. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2031 · Cited by 2,169
Sodroski, J. G., Rosen, C. A., & Haseltine, W. A. (1984) · Science · doi:10.1126/science.6330891 · Cited by 770
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
Felber, B. K., Paskalis, H., Kleinman-Ewing, C., Wong-Staal, F., & Pavlakis, G. N. (1985) · Science · doi:10.1126/science.2992082 · Cited by 516
Self-citation
Cited by
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation
Laspia, M. F., Rice, A. P., & Mathews, M. B. (1989) · Cell · doi:10.1016/0092-8674(89)90290-0 · Cited by 571
HIV-1 tat trans-activation requires the loop sequence within tar
Feng, S., & Holland, E. C. (1988) · Nature · doi:10.1038/334165a0 · Cited by 549
Stevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 441
Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes
Malim, M. H., Hauber, J., Fenrick, R., & Cullen, B. R. (1988) · Nature · doi:10.1038/335181a0 · Cited by 391
Metadata
- Authors
- Arya, S. K., Guo, C., Josephs, S. F., & Wong-Staal, F.
- Venue
- Science
- Published
- 1985-07-05
- Volume
- 229
- Issue
- 4708
- Pages
- 69-73
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998439550
- Cited by
- 858
- References
- 4
- FWCI
- 30.14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III). https://app.cochat.ai/papers/10.1126/science.2990040
- The paper
- Arya, S. K., Guo, C., Josephs, S. F., & Wong-Staal, F. (1985). Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III). Science. https://doi.org/10.1126/science.2990040
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
