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Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response
Open accessAbstract
Cell surface expression of the human cytomegalovirus (HCMV) major envelope glycoprotein complex, gp55-116 (gB), was studied by using monoclonal antibodies and an HCMV gp55-116 (gB) recombinant vaccinia virus. HCMV-infected human fibroblasts and recombinant vaccinia virus-infected HeLa cells expresses three electrophoretically distinct proteins of Mr 170,000, 116,000, and 55,000 on their surface. These species have been previously identified within infected cells and purified virions. Two unique neutralizing epitopes were shown to be present on the cell surface gp55-116 (gB). Utilizing HeLa cells infected with the gp55-116 recombinant vaccinia virus as a specific immunosorbent, we have shown that approximately 40 to 70% of the total serum virus-neutralizing activity of a group of individuals with past HCMV infections was directed against this single envelope glycoprotein. The implications of this finding for vaccine development are discussed.
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Cited by
Chou, S., & Dennison, K. M. (1991) · Journal of Infectious Diseases · doi:10.1093/infdis/163.6.1229 · Cited by 339
John, S., Yuzhakov, O., Woods, A., Deterling, J., Hassett, K., Shaw, C. A., & Ciaramella, G. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.029 · Cited by 229
The history of vaccination against cytomegalovirus
Plotkin, S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0388-z · Cited by 71
Metadata
- Authors
- Britt, W. J., Vugler, L., Butfiloski, E. J., & Stephens, E. B.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-03
- Volume
- 64
- Issue
- 3
- Pages
- 1079-1085
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1619193367
- Cited by
- 313
- References
- 0
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response. https://app.cochat.ai/papers/10.1128/jvi.64.3.1079-1085.1990
- The paper
- Britt, W. J., Vugler, L., Butfiloski, E. J., & Stephens, E. B. (1990). Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response. Journal of Virology. https://doi.org/10.1128/jvi.64.3.1079-1085.1990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
