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Cited by 339

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Analysis of Interstrain Variation in Cytomegalovirus Glycoprotein B Sequences Encoding Neutralization-Related Epitopes

Chou, S., Dennison, K. M.·1991·Journal of Infectious Diseases

Abstract

Nucleotide sequences of a part of the envelope glycoprotein B (gB) gene of human cytomegalovirus (CMV), encoding epitopes recognized by virus-neutralizing monoclonal antibodies, were determined for 12 distinct clinical strains of CMV after amplification of suitable templates using the polymerase chain reaction. Sequence analysis of this region (codons 384-717) revealed that the clinical strains and previously sequenced laboratory strains Towne and AD169 belong to one of four variant groups, each with a characteristic nucleotide and peptide sequence. Peptide homology was greater than 99% for strains within a group, and varied from 91% to 98% for strains in different groups. Variation was most frequent between codons 448 and 480. The gB group of a CMV strain could be determined by restriction analysis of a small target sequence amplified from viral genomic DNA, and an additional 28 clinical strains were grouped in this manner. The existence of a limited number of variants of gB among clinical strains facilitates analysis of biologic function and cross-reactivity of immune responses.

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Metadata

Authors
Chou, S., & Dennison, K. M.
Venue
Journal of Infectious Diseases
Published
1991-06-01
Volume
163
Issue
6
Pages
1229-1234
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2109645534
Cited by
339
References
12
FWCI
7.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Analysis of Interstrain Variation in Cytomegalovirus Glycoprotein B Sequences Encoding Neutralization-Related Epitopes. https://app.cochat.ai/papers/10.1093/infdis/163.6.1229
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Chou, S., & Dennison, K. M. (1991). Analysis of Interstrain Variation in Cytomegalovirus Glycoprotein B Sequences Encoding Neutralization-Related Epitopes. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/163.6.1229

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