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Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein
Open accessAbstract
MxA and MxB are interferon-induced proteins of human cells and are related to the murine protein Mx1, which confers selective resistance to influenza virus. In contrast to the nuclear murine protein Mx1, MxA and MxB are located in the cytoplasm, and their role in the interferon-induced antiviral state was unknown. In this report we show that transfected cell lines expressing MxA acquired a high degree of resistance to influenza A virus. Surprisingly, MxA also conferred resistance to vesicular stomatitis virus. Expression of MxA in transfected 3T3 cells had no effect on the multiplication of two picornaviruses, a togavirus, or herpes simplex virus type 1. Treatment of MxA-expressing cells with antibodies to mouse alpha-beta interferon did not abolish the resistance phenotype. The conclusion that resistance to influenza virus and vesicular stomatitis virus was due to the specific action of MxA is further supported by the observation that transfected 3T3 cell lines expressing the related MxB failed to acquire virus resistance.
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Citations
Cited by
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Dengue virus life cycle: viral and host factors modulating infectivity
Rodenhuis-Zybert, I. A., Wilschut, J., & Smit, J. M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0357-z · Cited by 499
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Ashour, J., Laurent-Rolle, M., Shi, P.-Y., & García-Sastre, A. (2009) · Journal of Virology · doi:10.1128/jvi.02188-08 · Cited by 451
Julkunen, I. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00026-5 · Cited by 354
The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection
Liu, Z., Pan, Q., Ding, S., Qian, J., Xu, F., Zhou, J., Cen, S., Guo, F., & Liang, C. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.08.015 · Cited by 334
Metadata
- Authors
- Pavlovic, J., Zürcher, T., Haller, O., & Staeheli, P.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-07
- Volume
- 64
- Issue
- 7
- Pages
- 3370-3375
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1605500799
- Cited by
- 401
- References
- 0
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. https://app.cochat.ai/papers/10.1128/jvi.64.7.3370-3375.1990
- The paper
- Pavlovic, J., Zürcher, T., Haller, O., & Staeheli, P. (1990). Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. Journal of Virology. https://doi.org/10.1128/jvi.64.7.3370-3375.1990
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
