RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence
Open accessAbstract
Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (positions 472 and 2493) show nucleotide heterogeneity. Propagation of the vaccine virus in cell cultures leads to rapid selection of virus with reversions at these two positions of the genome. The relative abundance of reversions at position 472 correlates with the results of monkey neurovirulence tests, while the mutation at position 2493 is not directly associated with neurovirulence of the virus in monkeys. Instead, the abundance of mutations at the latter position correlates with the source of the seed virus and its passage level. These results further indicate that MAPREC at position 472 can be used to assess the quality of poliovirus type 3 vaccine.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The key phenotypes of low neuropathogenicity for monkeys and temperature sensitivity are least stable for the Sabin 3 strain.
“These phenotypes are least stable for the Sabin 3 strain (28), which has the highest variability across production lots and is also associated with the highest incidence of VAPP among OPV recipients (see below).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [28]
Cites
Evans, D. M. A., Dunn, G., Minor, P. D., Schild, G. C., Cann, A. J., Stanway, G., Almond, J. W., Currey, K., & Maizel, J. V. (1985) · Nature · doi:10.1038/314548a0 · Cited by 440 · see citing works
Complete nucleotide sequences of all three poliovirus serotype genomes
Toyoda, H., Kohara, M., Kataoka, Y., Suganuma, T., Omata, T., Imura, N., & Nomoto, A. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90084-6 · Cited by 418 · see citing works
Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine
Westrop, G. D., Wareham, K. A., Evans, D. M. A., Dunn, G., Minor, P. D., Magrath, D. I., Taffs, F., Marsden, S. A., Skinner, M. A., & Schild, G. C. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1338-1344.1989 · Cited by 232 · see citing works
Stanway, G., Hughes, P. J., Mountford, R. C., Reeve, P., Minor, P. D., Schild, G. C., & Almond, J. W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1539 · Cited by 188 · see citing works
Chumakov, K., Powers, L., Noonan, K. E., Roninson, I. B., & Levenbook, I. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.199 · Cited by 153 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703 · see citing works
Live attenuated vaccines: Historical successes and current challenges
Minor, P. D. (2015) · Virology · doi:10.1016/j.virol.2015.03.032 · Cited by 494 · see citing works
Molecular Typing of Enteroviruses: Current Status and Future Requirements
Muir, P., Kämmerer, U., Korn, K., Mulders, M. N., Pöyry, T. A. A., Weißbrich, B., Kandolf, R., Cleator, G. M., & van Loon, A. M. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.202 · Cited by 241 · see citing works
The molecular biology of poliovaccines
Minor, P. D. (1992) · Journal of General Virology · doi:10.1099/0022-1317-73-12-3065 · Cited by 217 · see citing works
Nielsen, H. S., Oleksiewicz, M. B., Forsberg, R., Stadejek, T., Bøtner, A. G., & Storgaard, T. (2001) · Journal of General Virology · doi:10.1099/0022-1317-82-6-1263 · Cited by 203 · see citing works
Guirakhoo, F., Zhang, Z.-X., Chambers, T. J., Delagrave, S., Arroyo, J., Barrett, A. D. T., & Monath, T. P. C. (1999) · Virology · doi:10.1006/viro.1999.9695 · Cited by 171 · see citing works
Sutter, R. W., Kew, O. M., & Cochi, S. L. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-3611-1.50030-1 · Cited by 167 · see citing works
Molecular epidemiology of polioviruses
Kew, O. M., Mulders, M. N., Lipskaya, G. Y., da Silva, E. E., & Patlansch, M. A. (1995) · Seminars in Virology · doi:10.1016/s1044-5773(05)80017-4 · Cited by 157 · see citing works
Shih, S., Ho, M.-S., Lin, K.-H., Wu, S.-L., Chen, Y.-T., Wu, C.-N., Lin, T., Chang, L., Tsao, K., Ning, H., et al. (2000) · Virus Research · doi:10.1016/s0168-1702(00)00162-3 · Cited by 146 · see citing works
Blomqvist, S., Bruu, A., Stenvik, M., & Hovi, T. (2003) · Journal of General Virology · doi:10.1099/vir.0.18708-0 · Cited by 94 · see citing works
Yan, J., Su, I., Chen, P., Liu, C., Yu, C., & Wang, J. (2001) · Journal of Medical Virology · doi:10.1002/jmv.2038 · Cited by 81 · see citing works
Famulare, M., Chang, S. T., Iber, J. C., Zhao, K., Adeniji, J. A., Bukbuk, D. N., Baba, M., Behrend, M. R., Burns, C. C., & Oberste, M. S. (2015) · Journal of Virology · doi:10.1128/jvi.01532-15 · Cited by 72 · see citing works
Neverov, A., & Chumakov, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012537107 · Cited by 68 · see citing works
Self-citationMonath, T. P. C., Myers, G. A., Beck, R. A., Knauber, M., Scappaticci, K., Pullano, T. G., Archambault, W. T., Catalan, J., Miller, C., Zhang, Z.-X., et al. (2005) · Biologicals · doi:10.1016/j.biologicals.2005.03.009 · Cited by 59 · see citing works
Self-citationSutter, R. W., Kew, O. M., Cochi, S. L., & Aylward, R. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-0090-5.00035-5 · Cited by 55 · see citing works
Zheng, Z., He, P., Caueffield, D., Neumann, M., Specter, S. C., Baker, C. C., & Bankowski, M. J. (1995) · Journal of Medical Virology · doi:10.1002/jmv.1890470209 · Cited by 54 · see citing works
Characterisation of vaccine-derived polioviruses isolated from sewage and river water in Japan
Yoshida, H., Horie, H., Matsuura, K., & Miyamura, T. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02868-3 · Cited by 51 · see citing works
Amexis, G., Oeth, P. A., Abel, K. J., Ivshina, A. V., Pelloquin, F., Cantor, C. R., Braun, A. D., & Chumakov, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211423298 · Cited by 50 · see citing works
Self-citationReverse transcriptase can inhibit PCR and stimulate primer-dimer formation.Preprint
Chumakov, K. (1994) · Genome Research · doi:10.1101/gr.4.1.62 · Cited by 46 · see citing works
Self-citationMueller, J. E., Bessaud, M., Huang, Q. S., Martínez, L. C., Barril, P. A., Morel, V., Balanant, J., Bocacao, J., Hewitt, J., Gessner, B. D., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02201-08 · Cited by 45 · see citing works
van der Sanden, S. M. G., Wu, W., Dybdahl-Sissoko, N., Weldon, W. C., Brooks, P., O’Donnell, J., Jones, L. P., Brown, C. J., Tompkins, S. M., Oberste, M. S., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01464-15 · Cited by 45 · see citing works
The Mumps Virus Neurovirulence Safety Test in Rhesus Monkeys:A Comparison of Mumps Virus Strains
Rubin, S. A., Snoy, P. J., Wright, K. E., Brown, E. G., Reeve, P., Beeler, J. A., & Carbone, K. M. (1999) · The Journal of Infectious Diseases · doi:10.1086/314905 · Cited by 45 · see citing works
A developing country perspective on vaccine-associated paralytic poliomyelitis.
John, T. J. (2004) · Europe PMC (PubMed Central) · doi:10.1590/s0042-96862004000100011 · Cited by 43 · see citing works
Chumakov, K. M., Dragunsky, E. M., Norwood, L. P., Douthitt, M., Ran, Y., Taffs, R. E., Ridge, J., & Levenbook, I. S. (1994) · Journal of Medical Virology · doi:10.1002/jmv.1890420115 · Cited by 42 · see citing works
Self-citationMutations in Sabin 2 Strain of Poliovirus and Stability of Attenuation Phenotype
Rezapkin, G. V., Fan, L., Asher, D. M., Fibi, M. R., Dragunsky, E. M., & Chumakov, K. M. (1999) · Virology · doi:10.1006/viro.1999.9718 · Cited by 40 · see citing works
Self-citationMatsuura, K., Ishikura, M., Yoshida, H., Nakayama, T., Hasegawa, S., Ando, S., Horie, H., Miyamura, T., & Kitamura, T. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.11.5087-5091.2000 · Cited by 37 · see citing works
Proudnikov, D., Kirillov, E., Chumakov, K., Donlon, J. A., Rezapkin, G. V., & Mirzabekov, A. D. (2000) · Biologicals · doi:10.1006/biol.1999.0241 · Cited by 34 · see citing works
Self-citationTao, Z., Wang, H., Xu, A., Zhang, Y., Song, L., Zhu, S., Li, Y., Yan, D., Liu, G., Yoshida, H., et al. (2010) · Virus Research · doi:10.1016/j.virusres.2010.02.014 · Cited by 33 · see citing works
Molecular Evidence of RNA Editing in Bombyx Chemosensory Protein Family
Ning, X., Bu, X., Liu, Y. Y., Yang, X., Liu, G. X., Fan, Z. X., Bi, Y. P., Yang, L., Lou, Q., Rajashekar, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086932 · Cited by 31 · see citing works
Chumakov, K. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.7331-7334.1996 · Cited by 30 · see citing works
Self-citationQuantitative aspects of the mutant analysis by PCR and restriction enzyme cleavage (MAPREC).Preprint
Lu, Z., Douthitt, M., Taffs, R. E., Ran, Y., Norwood, L. P., & Chumakov, K. (1993) · Genome Research · doi:10.1101/gr.3.3.176 · Cited by 25 · see citing works
Self-citationvan der Sanden, S., Pallansch, M. A., van de Kassteele, J., El-Sayed, N., Sutter, R. W., Koopmans, M., & van der Avoort, H. (2009) · Journal of Virology · doi:10.1128/jvi.02388-08 · Cited by 24 · see citing works
Genomic Analysis of Recombinant Sabin Clinical Isolates
Paximadi, E., Karakasiliοtis, I., Mamuris, Z., Stathopoulos, C., Krikelis, V., & Markoulatos, P. (2006) · Virus Genes · doi:10.1007/s11262-005-6877-1 · Cited by 24 · see citing works
Schlesinger, R. W., Husak, P. J., Bradshaw, G. L., & Panayotov, P. P. (1998) · Advances in virus research · doi:10.1016/s0065-3527(08)60811-8 · Cited by 24 · see citing works
Sutter, R. W., Kew, O. M., Cochi, S. L., & Aylward, R. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35761-6.00048-1 · Cited by 22 · see citing works
Intratypic genome variability of the coxsackievirus B1 2A protease region
Zoll, J., Galama, J. M. D., & Melchers, W. J. G. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-3-687 · Cited by 19 · see citing works
Chezzi, C., Dommann, C. J., Blackburn, N. K., Maselesele, E., McAnerney, J., & Schoub, B. D. (1998) · Vaccine · doi:10.1016/s0264-410x(98)00079-6 · Cited by 17 · see citing works
Wang, X., Sun, L., Lǐ, Y., Lin, T., Gao, F., Yao, H., He, K., Tong, G., Wei, Z., & Yuan, S. (2012) · Virus Research · doi:10.1016/j.virusres.2012.11.006 · Cited by 15 · see citing works
Lessons from Vaccine-Related Poliovirus in Israel, UK and USA
John, T. J., & Dharmapalan, D. (2022) · Vaccines · doi:10.3390/vaccines10111969 · Cited by 15 · see citing works
Laassri, M., Bidzhieva, B., Speicher, J. M., Pletnev, A. G., & Chumakov, K. (2011) · Journal of Medical Virology · doi:10.1002/jmv.22033 · Cited by 15 · see citing works
Self-citationRecombinant Sabin environmental isolates in Greece and Cyprus
Paximadi, E., Karakasiliοtis, I., Papaventsis, D. C., Papageorgiou, G. T., & Markoulatos, P. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03649.x · Cited by 15 · see citing works
Lu, Z., Rezapkin, G. V., Douthitt, M., Ran, Y., Asher, D. M., Levenbook, I. S., & Chumakov, K. (1996) · Journal of General Virology · doi:10.1099/0022-1317-77-2-273 · Cited by 15 · see citing works
Self-citationMallet, L., Pelloquin, F., Brigaud, M., Caudrelier, P., Bandet, R., Xueref, C., Fuchs, F., Gibelin, N., Goldman, C., Moulin, J.-C., et al. (1997) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199705)52:1 · Cited by 15 · see citing works
Neurovirulence of Type 1 Polioviruses Isolated from Sewage in Japan
Horie, H., Yoshida, H., Matsuura, K., Miyazawa, M., Ota, Y., Nakayama, T., Doi, Y., & Hashizume, S. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.138-142.2002 · Cited by 15 · see citing works
Horie, H., Miyazawa, M., Ota, Y., Wakabayashi, K., Yoshida, H., Doi, Y., & Hashizume, S. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00350-9 · Cited by 11 · see citing works
Hellen, C. U. T., & Wimmer, E. (2014) · ASM Press eBooks · doi:10.1128/9781555818326.ch2 · Cited by 11 · see citing works
Dragunsky, E. M. (1997) · Vaccine · doi:10.1016/s0264-410x(97)00142-4 · Cited by 10 · see citing works
Self-citationLive Viral Vaccine Neurovirulence Screening: Current and Future Models
Fulton, C. M., & Bailey, W. J. (2021) · Vaccines · doi:10.3390/vaccines9070710 · Cited by 9 · see citing works
Reevaluation of nucleotide sequences of wild-type and attenuated polioviruses of type 3
Rezapkin, G. V., Douthitt, M., Dragunsky, E. M., & Chumakov, K. M. (1999) · Virus Research · doi:10.1016/s0168-1702(99)00108-2 · Cited by 9 · see citing works
Self-citationThe role of non-human primates in the neurological safety of live viral vaccines (review)
Levenbook, I. S. (2010) · Biologicals · doi:10.1016/j.biologicals.2010.11.003 · Cited by 8 · see citing works
Self-citationKew, O. M. (2014) · Springer eBooks · doi:10.1007/978-1-4899-7448-8_13 · Cited by 8 · see citing works
Shulman, L. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5719-0_10 · Cited by 7 · see citing works
Deng, Y., Cai, W., Li, J., Li, Y., Yang, X., Ma, Y., Yao, Y., Yang, L., Shi, L., & Sun, M. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.11.020 · Cited by 7 · see citing works
Thorley, B. R., Kelly, H. A., Nishimura, Y., Yoon, Y. K., Brussen, K. A., Roberts, J., & Shimizu, H. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.01.014 · Cited by 7 · see citing works
Gulija, T. K., Ivančić-Jelečki, J., Šantak, M., & Forčić, D. (2011) · Electrophoresis · doi:10.1002/elps.201100010 · Cited by 7 · see citing works
de Andrade, A. A. S., Soares, A. E. R., de Almeida, L. G. P., Ciapina, L. P., Pestana, C. P., Aquino, C., Medeiros, M. A., & de Vasconcelos, A. T. R. (2021) · Interface Focus · doi:10.1098/rsfs.2020.0063 · Cited by 6 · see citing works
Human enterovirus isolates from an outbreak typed using heteroduplex mobility analysis
Clancy, L. E., Craig, M. E., White, P. A., & Rawlinson, W. D. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20344 · Cited by 6 · see citing works
Berre, V. L., Baranowski, É., Deplanche, M., Trouilh, L., & François, J. (2007) · Journal of Virological Methods · doi:10.1016/j.jviromet.2007.10.026 · Cited by 5 · see citing works
Rapid and accurate identification of poliovirus strains used for vaccine production
Nijst, O. E. M., Mouthaan, J., Mekkes, D. R., Jusic, E., van der Avoort, H. G. A. M., & Metz, B. (2013) · Journal of Virological Methods · doi:10.1016/j.jviromet.2013.01.026 · Cited by 5 · see citing works
Poliovirus Neurovirulence and its Attenuation
Agol, V. I. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2928-6_21 · Cited by 4 · see citing works
Shulman, L. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0851-3_839 · Cited by 4 · see citing works
Detection of Mutants in Polio Vaccine Viruses Using Pooled Antipoliovirus Monoclonal Antibodies
Horie, H., Miyazawa, M., Ota, Y., Wakabayashi, K., Doi, T., Yoshizawa, K., Doi, Y., & Hashizume, S. (1999) · Biologicals · doi:10.1006/biol.1999.0211 · Cited by 3 · see citing works
Thomas (2010) · Springer eBooks · doi:10.1007/978-3-0346-0277-8_3 · Cited by 2 · see citing works
Zheng, Z., Bankowski, M. J., He, P.-J., Caueffield, D., Neumann, M. A., & Specter, S. C. (1993) · Clinical and Diagnostic Virology · doi:10.1016/0928-0197(93)90022-w · Cited by 2 · see citing works
Estívariz, C. F., Burns, C. C., & Macklin, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00050-5 · Cited by 2 · see citing works
Polioviruses and the Endgame Strategy for Global Polio Eradication
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005)
Dynamics of genomic variation in poliovirus in Africa
Chezzi, C. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Shulman, L. M. (2020) · Springer eBooks · doi:10.1007/978-1-4939-2493-6_839-3
Shulman, L. M. (2023) · Encyclopedia of sustainability science and technology series · doi:10.1007/978-1-0716-2463-0_839
Ανασυνδυασμένα στελέχη πολιοϊών - θέσεις γενετικού ανασυνδυασμού
Paximadi, E. (2009) · doi:10.12681/eadd/17217
Prevalence and Genetic Diversity of Human Enteroviruses in the Context of Poliovirus Eradication
van der Sanden, S. (2012) · Rivm (National Institute for Public Health and the Environment)
- Authors
- Chumakov, K. M., Norwood, L. P., Parker, M. L., Dragunsky, E. M., Ran, Y. X., & Levenbook, I. S.
- Affiliations
- Center for Biologics Evaluation and Research (US)
- ORCID
- Chumakov, K M
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1992-02
- Volume
- 66
- Issue
- 2
- Pages
- 966-970
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC240798
- OpenAlex
- W1517149542
- Cited by
- 72
- References
- 5
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- oral polio vaccine, neurovirulence, reversion mutations
- MeSH terms
- Animals, Base Sequence, Macaca, Molecular Sequence Data, Mutation, Poliovirus Vaccine, Oral, Genetic Variation, Virulence, Restriction Mapping, Polymerase Chain Reaction, Genome, Viral, Poliovirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review