The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture
Open accessAbstract
Human T-cell leukemia virus type 1 (HTLV-1) immortalizes human CD4+ T lymphocytes in culture. Previous studies show that in the context of a herpesvirus saimiri vector, the sequence of the X region at the 3' end of the HTLV-1 genome is also capable of immortalizing CD4+ lymphocytes in the absence of HTLV-1 structural proteins. The X region of HTLV-1 encodes two trans-acting viral proteins, the 42-kDa Tax protein and the 27-kDa Rex protein. Infection of human cord blood cells with herpesvirus saimiri recombinants which contain HTLV-1 X region sequences defective for expression of tax, rex, or both tax and rex demonstrates that tax function is necessary and sufficient for immortalization of primary human CD4+ cord blood lymphocytes in culture in the context of the herpesvirus saimiri vector.
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The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice
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Cited by
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
Migone, T.-S., Lin, J.-X., Cereseto, A., Mulloy, J. C., O'Shea, J. J., Franchini, G., & Leonard, W. J. (1995) · Science · doi:10.1126/science.7604283 · Cited by 557
Arnold, J., Yamamoto, B., Li, M., Phipps, A. J., Younis, I., Lairmore, M. D., & Green, P. L. (2006) · Blood · doi:10.1182/blood-2005-11-4551 · Cited by 196
HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways
Currer, R., Van Duyne, R., Jaworski, E., Guendel, I., Sampey, G., Das, R., Narayanan, A., & Kashanchi, F. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00406 · Cited by 156
Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis
Kannian, P., & Green, P. L. (2010) · Viruses · doi:10.3390/v2092037 · Cited by 139
Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P., & Bangham, C. R. M. (2009) · Blood · doi:10.1182/blood-2008-03-136770 · Cited by 118
Metadata
- Authors
- Grassmann, R., Berchtold, S., Radant, I., Alt, M., Fleckenstein, B., Sodroski, J. G., Haseltine, W. A., & Ramstedt, U.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1992-07
- Volume
- 66
- Issue
- 7
- Pages
- 4570-4575
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1622349285
- Cited by
- 314
- References
- 50
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. https://app.cochat.ai/papers/10.1128/jvi.66.7.4570-4575.1992
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- Grassmann, R., Berchtold, S., Radant, I., Alt, M., Fleckenstein, B., Sodroski, J. G., Haseltine, W. A., & Ramstedt, U. (1992). Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. Journal of Virology. https://doi.org/10.1128/jvi.66.7.4570-4575.1992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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