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The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein
Open accessAbstract
The human papillomavirus (HPV) E5 proteins are predicted from DNA sequence analysis to be small hydrophobic molecules, and the HPV type 6 (HPV-6) and HPV-11 E5 proteins share several structural similarities with the bovine papillomavirus type 1 (BPV-1) E5 protein. Also similar to the BPV-1 E5 protein, the HPV-6 and HPV-16 E5 proteins exhibit transforming activity when assayed on NIH 3T3 and C127 cells. In this study, we expressed epitope-tagged E5 proteins from both the "low-risk" HPV-6 and the "high-risk" HPV-16 in order to permit their immunologic identification and biochemical characterization. While the HPV-6 and HPV-16 E5 proteins fail to form disulfide-linked dimers and oligomers, they did resemble the BPV-1 E5 protein in their intracellular localization to the Golgi apparatus, endoplasmic reticulum, and nuclear membranes. In addition, the HPV E5 proteins also bound to the 16-kDa pore-forming protein component of the vacuolar ATPase, a known characteristic of the BPV-1 E5 protein. These studies reveal a common intramembrane localization and potential cellular protein target for both the BPV and HPV E5 proteins.
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Cited by
Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity
Hebner, C. M., & Laimins, L. A. (2006) · Reviews in Medical Virology · doi:10.1002/rmv.488 · Cited by 401
E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I
Ashrafi, G. H., Haghshenas, M. R., Marchetti, B., O'Brien, P. M., & Campo, M. S. (2005) · International Journal of Cancer · doi:10.1002/ijc.20558 · Cited by 192
Lazarczyk, M., Cassonnet, P., Pons, C., Jacob, Y., & Favre, M. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00033-08 · Cited by 131
Ashrafi, G. H., Haghshenas, M., Marchetti, B., & Campo, M. S. (2006) · International Journal of Cancer · doi:10.1002/ijc.22089 · Cited by 131
Genther Williams, S. M., Disbrow, G. L., Schlegel, R., Lee, D., Threadgill, D. W., & Lambert, P. F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0083 · Cited by 125
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Metadata
- Authors
- Conrad, M., Bubb, V. J., & Schlegel, R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1993-10
- Volume
- 67
- Issue
- 10
- Pages
- 6170-6178
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1581360649
- Cited by
- 248
- References
- 0
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Conrad, M., Bubb, V. J., & Schlegel, R. (1993). The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein. Journal of Virology. https://doi.org/10.1128/jvi.67.10.6170-6178.1993
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