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La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
Open accessAbstract
Translation initiation on poliovirus RNA occurs by internal binding of ribosomes to a sequence within the 5' untranslated region. We have previously characterized a HeLa cell protein, p52, that binds to a fragment of the poliovirus 5' untranslated region (K. Meerovitch, J. Pelletier, and N. Sonenberg, Genes Dev. 3:1026-1034, 1989). Here we report the purification of the HeLa p52. Protein microsequencing identified p52 as La autoantigen. The La protein is a human antigen that is recognized by antibodies from patients with autoimmune disorders such as systemic lupus erythematosus and Sjögren's syndrome. We show that the La protein stimulates translation of poliovirus RNA, but not brome mosaic virus, tobacco mosaic virus, and alfalfa mosaic virus 4 RNA, translation in a reticulocyte lysate. In addition, La corrects aberrant translation of poliovirus RNA in a reticulocyte lysate. Subcellular immunolocalization showed that La protein is mainly nuclear, but after poliovirus infection, La is redistributed to the cytoplasm. Our results suggest that La protein is involved in poliovirus internal initiation of translation and might function through a similar mechanism in the translation of cellular mRNAs.
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Citations
Cited by
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A.-C., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,121
Self-citationInitiation of translation in prokaryotes and eukaryotes
Kozak, M. (1999) · Gene · doi:10.1016/s0378-1119(99)00210-3 · Cited by 1,364
Kedersha, N. L., Gupta, M., Li, W., Miller, I., & Anderson, P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1431 · Cited by 1,256
Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs
Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766
Switch from translation to RNA replication in a positive-stranded RNA virus
Gamarnik, A. V., & Andino, R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2293 · Cited by 508
Metadata
- Authors
- Meerovitch, K., Svitkin, Y. V., Lee, H. S., Lejbkowicz, F., Kenan, D. J., Chan, E. K., Agol, V. I., Keene, J. D., & Sonenberg, N.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1993-07
- Volume
- 67
- Issue
- 7
- Pages
- 3798-3807
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1620364639
- Cited by
- 493
- References
- 0
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. https://app.cochat.ai/papers/10.1128/jvi.67.7.3798-3807.1993
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- Meerovitch, K., Svitkin, Y. V., Lee, H. S., Lejbkowicz, F., Kenan, D. J., Chan, E. K., Agol, V. I., Keene, J. D., & Sonenberg, N. (1993). La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. Journal of Virology. https://doi.org/10.1128/jvi.67.7.3798-3807.1993
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