The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Switch from translation to RNA replication in a positive-stranded RNA virus
Open accessAbstract
In positive-stranded viruses, the genomic RNA serves as a template for both translation and RNA replication. Using poliovirus as a model, we examined the interaction between these two processes. We show that the RNA polymerase is unable to replicate RNA templates undergoing translation. We discovered that an RNA structure at the 5′ end of the viral genome, next to the internal ribosomal entry site, carries signals that control both viral translation and RNA synthesis. The interaction of this RNA structure with the cellular factor PCBP up-regulates viral translation, while the binding of the viral protein 3CD represses translation and promotes negative-strand RNA synthesis. We propose that the interaction of 3CD with this RNA structure controls whether the genomic RNA is used for translation or RNA replication.
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Cites
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Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs
Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766
Ostareck, D. H., Ostareck-Lederer, A., Wilm, M., Thiele, B. J., Mann, M., & Hentze, M. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80241-x · Cited by 502
Poliovirus RNA synthesis utilizes an RNP complex formed around the 5′-end of viral RNA.
Andino, R., Rieckhof, G. E., Achacoso, P. L., & Baltimore, D. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06032.x · Cited by 494
Self-citationA functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA
Andino, R., Rieckhof, G. E., & Baltimore, D. (1990) · Cell · doi:10.1016/0092-8674(90)90170-j · Cited by 494
Self-citationLa autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
Meerovitch, K., Svitkin, Y. V., Lee, H. S., Lejbkowicz, F., Kenan, D. J., Chan, E. K., Agol, V. I., Keene, J. D., & Sonenberg, N. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3798-3807.1993 · Cited by 493
Pestova, T. V., Hellen, C. U. T., & Shatsky, I. N. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6859 · Cited by 491
Cell-Free, De Novo Synthesis of Poliovirus
Molla, A., Paul, A. V., & Wimmer, E. (1991) · Science · doi:10.1126/science.1661029 · Cited by 373
Flanegan, J. B., Petterson, R. F., Ambros, V, Hewlett, N. J., & Baltimore, D. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.3.961 · Cited by 347
Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond.
Jackson, R. J., & Kaminski, A. (1995) · Europe PMC (PubMed Central) · Cited by 346
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The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms
MAKEYEV, A. V., & LIEBHABER, S. A. (2002) · RNA · doi:10.1017/s1355838202024627 · Cited by 470
The encephalomyocarditis virus
Carocci, M., & Bakkali-Kassimi, L. (2012) · Virulence · doi:10.4161/viru.20573 · Cited by 231
Insight into the Life Cycle of Enterovirus-A71
Liu, Q., & Long, J.-E. (2025) · Viruses · doi:10.3390/v17020181 · Cited by 11
Metadata
- Authors
- Gamarnik, A. V., & Andino, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-08-01
- Volume
- 12
- Issue
- 15
- Pages
- 2293-2304
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2099378833
- Cited by
- 508
- References
- 44
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
