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Cited by 848

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

Kowalski, Mark, Potz, Joseph, Basiripour, Ladan, Dorfman, Tatyana, Goh, Wei Chun, Terwilliger, Ernest, Dayton, Andrew, Rosen, Craig, Haseltine, William, Sodroski, Joseph·1987·Science

Abstract

The envelope of the human immunodeficiency virus type 1 (HIV-1) plays a central role in the process of virus entry into the host cell and in the cytopathicity of the virus for lymphocytes bearing the CD4 molecule. Mutations that affect the ability of the envelope glycoprotein to form syncytia in CD4 + cells can be divided into five groups: those that decrease the binding of the envelope protein to the CD4 molecule, those that prevent a post-binding fusion reaction, those that disrupt the anchorage of the envelope glycoprotein in the membrane, those that affect the association of the two subunits of the envelope glycoprotein, and those that affect post-translational proteolytic processing of the envelope precursor protein. These findings provide a functional model of the HIV envelope glycoprotein.

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Crossref · 10.1126/science.3629244

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Metadata

Authors
Kowalski, M., Potz, J., Basiripour, L., Dorfman, T., Goh, W. C., Terwilliger, E., Dayton, A., Rosen, C., Haseltine, W., & Sodroski, J.
Venue
Science
Published
1987-09-11
Volume
237
Issue
4820
Pages
1351-1355
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1986159600
Cited by
848
References
1
FWCI
16.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1. https://app.cochat.ai/papers/10.1126/science.3629244
The paper
Kowalski, M., Potz, J., Basiripour, L., Dorfman, T., Goh, W. C., Terwilliger, E., Dayton, A., Rosen, C., Haseltine, W., & Sodroski, J. (1987). Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1. Science. https://doi.org/10.1126/science.3629244

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.