The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
Open accessAbstract
A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inverted terminal repeat at the right end of the genome. In the NZ2 strain of OV (OV NZ2), the gene encodes a polypeptide with a molecular size of 14.7 kDa, while in another strain, OV NZ7, there is a variant gene that encodes a polypeptide of 16 kDa. The OV NZ2 and OV NZ7 polypeptides show 22 to 27% and 16 to 23% identity, respectively, to the mammalian VEGFs. The viral polypeptides are only 41.1% identical to each other, and there is little homology between the two genes at the nucleotide level. Another unusual feature of these genes is their G+C content, particularly that of OV NZ7. In a genome that is otherwise 63% G+C, the OV NZ2 gene is 57.2% G+C and the OV NZ7 gene is 39.7% G+C. The OV NZ2 gene, but not the OV NZ7 gene, is homologous to the mammalian VEGF genes at the DNA level, suggesting that the gene has been acquired from a mammalian host and is undergoing genetic drift. The lesions induced in sheep and humans after infection with OV show extensive dermal vascular endothelial proliferation and dilatation, and it is likely that this is a direct effect of the expression of the VEGF-like gene.
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Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 4,986
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer
Higgins, D. G., & Sharp, P. M. (1988) · Gene · doi:10.1016/0378-1119(88)90330-7 · Cited by 3,394
Ferrara, N., & Henzel, W. J. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92678-8 · Cited by 2,268
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,061
The biology of platelet-derived growth factor
Ross, R., Raines, E. W., & Bowen-Pope, D. F. (1986) · Cell · doi:10.1016/0092-8674(86)90733-6 · Cited by 2,008
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
Maglione, D., Guerriero, V, Viglietto, G., Delli-Bovi, P., & Persico, M. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9267 · Cited by 999
The complete DNA sequence of vaccinia virus
Goebel, S. J., Johnson, G. P., Perkus, M. E., Davis, S. W., Winslow, J. P., & Paoletti, E. (1990) · Virology · doi:10.1016/0042-6822(90)90294-2 · Cited by 850
The vascular endothelial growth factor family of polypeptides
Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., & Leung, D. W. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470305 · Cited by 641
Gospodarowicz, D., Abraham, J. A., & Schilling, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7311 · Cited by 559
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The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,330
Shibuya, M. (2011) · Genes & Cancer · doi:10.1177/1947601911423031 · Cited by 1,748
Nishida, N., Yano, H., Nishida, T., Kamura, T., & Kojiro, M. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.3.213 · Cited by 1,434
Molecular and biological properties of vascular endothelial growth factor
Ferrara, N. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900019 · Cited by 1,158
Role of vascular endothelial growth factor in regulation of physiological angiogenesis
Ferrara, N. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.6.c1358 · Cited by 1,085
Metadata
- Authors
- Lyttle, D. J., Fraser, K. M., Fleming, S. B., Mercer, A. A., & Robinson, A. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-01
- Volume
- 68
- Issue
- 1
- Pages
- 84-92
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1582316077
- Cited by
- 303
- References
- 25
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyttle, D. J., Fraser, K. M., Fleming, S. B., Mercer, A. A., & Robinson, A. J. (1994). Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. Journal of Virology. https://doi.org/10.1128/jvi.68.1.84-92.1994
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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