The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Role of vascular endothelial growth factor in regulation of physiological angiogenesis
Abstract
Evidence accumulating over the last decade has established the fundamental role of vascular endothelial growth factor (VEGF) as a key regulator of normal and abnormal angiogenesis. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2). The signaling and biological properties of these two receptors are strikingly different. VEGF is essential for early development of the vasculature to the extent that inactivation of even a single allele of the VEGF gene results in embryonic lethality. VEGF is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF as an angiogenic mediator in tumors and intraocular neovascular syndromes, and numerous clinical trials are presently testing the hypothesis that inhibition of VEGF may have therapeutic value.
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Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
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Self-citationVascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
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Tumors: Wounds That Do Not Heal
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Self-citationAbnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,117
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
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Self-citationHeterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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Cited by
VEGF as a Key Mediator of Angiogenesis in Cancer
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Mechanisms of Acetaminophen-Induced Liver Necrosis
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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
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Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix
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Metadata
- Authors
- Ferrara, N.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- C1358-C1366
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2107436171
- Cited by
- 1,085
- References
- 112
- FWCI
- 24.43
- Type
- journal article
- Language
- en
- Open access
- closed
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