The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses?
Open accessAbstract
Dinucleotide over- and underrepresentation is evaluated in all available completely sequenced DNA or RNA viral genomes, ranging in size from 3 to 250 kb (available RNA viruses fall into the small-virus category). The dinucleotide CpG is statistically underrepresented (suppressed) in all but four of the small viruses (more than 75 with lengths of < 30 kb) but has normal relative abundances in most large viruses (> or = 30 kb). Most retrotransposons in eukaryotic species also show low CpG relative abundances. Interpretations, especially in some cases of DNA viruses or viruses with a DNA intermediate, might relate to methylation effects and modes of viral integration and excision. Other possible contributing factors relate to dinucleotide stacking energies, special mutation mechanisms, and evolutionary events.
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Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Nonparametric Statistical Methods
(1999) · Technometrics · doi:10.1080/00401706.1999.10485954 · Cited by 6,090
Predicting DNA duplex stability from the base sequence
Breslauer, K. J., Frank, R., Blöcker, H., & Marky, L. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3746 · Cited by 1,837
DNA METHYLATION AND GENE ACTIVITY
Doerfler, W. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.000521 · Cited by 1,098
Self-citationThe Inheritance of Epigenetic Defects
Holliday, R. (1987) · Science · doi:10.1126/science.3310230 · Cited by 1,082
The CpG dinucleotide and human genetic disease
Cooper, D. N., & Youssoufian, H. (1988) · Human Genetics · doi:10.1007/bf00278187 · Cited by 931
Enzymatic Synthesis of Deoxyribonucleic Acid
Josse, J., Kaiser, A. D., & Kornberg, A. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64321-2 · Cited by 753
5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes
Rideout, W. M., Coetzee, G. A., Olumi, A. F., & Jones, P. A. (1990) · Science · doi:10.1126/science.1697983 · Cited by 640
PREMEIOTIC INSTABILITY OF REPEATED SEQUENCES IN NEUROSPORA CRASSA
Selker, E. U. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.003051 · Cited by 638
MAMMALIAN X-CHROMOSOME INACTIVATION
Gartler, S. M., & Riggs, A. D. (1983) · Annual Review of Genetics · doi:10.1146/annurev.ge.17.120183.001103 · Cited by 635
Cited by
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
Lund, J., Sato, A., Akira, S., Medzhitov, R., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,198
Dinucleotide relative abundance extremes: a genomic signature
Kariin, S., & Burge, C. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89076-9 · Cited by 701
Beignon, A.-S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26032 · Cited by 673
CG dinucleotide suppression enables antiviral defence targeting non-self RNA
Takata, M. A., Gonçalves-Carneiro, D., Zang, T. M., Soll, S. J., York, A., Blanco-Melo, D., & Bieniasz, P. D. (2017) · Nature · doi:10.1038/nature24039 · Cited by 398
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
Krieg, A. M., Wu, T., Weeratna, R., Efler, S. M., Love-Homan, L., Yang, L., Yi, A.-K., Short, D., & Davis, H. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12631 · Cited by 397
Metadata
- Authors
- Karlin, S., Doerfler, W., & Cardon, L. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-05
- Volume
- 68
- Issue
- 5
- Pages
- 2889-2897
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2161167739
- Cited by
- 326
- References
- 45
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? https://app.cochat.ai/papers/10.1128/jvi.68.5.2889-2897.1994
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- Karlin, S., Doerfler, W., & Cardon, L. R. (1994). Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? Journal of Virology. https://doi.org/10.1128/jvi.68.5.2889-2897.1994
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
