The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Inheritance of Epigenetic Defects
Abstract
Evidence from many sources shows that the control of gene expression in higher organisms is related to the methylation of cytosine in DNA, and that the pattern of methylation is inherited. Loss of methylation, which can result from DNA damage, will lead to heritable abnormalities in gene expression, and these may be important in oncogenesis and aging. Transformed permanent lines often lose gene activity through de novo methylation. It is proposed that epigenetic defects in germline cells due to loss of methylation can be repaired by recombination at meiosis but that some are transmitted to offspring.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831
On the nature of the aging process
Szilard, L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.30 · Cited by 651
Cited by
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,191
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097
“Aberrant DNA methylation could be repaired via meiosis, but some patterns are still transmitted to offspring.(2) This phenomenon covers a wide range of cellular activities, such as cell growth, differentiation, and disease development, and is heritable.”
BackgroundOxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106
Endogenous Oxidative DNA Damage, Aging, and Cancer
Ames, B. N. (1989) · Free Radical Research Communications · doi:10.3109/10715768909087933 · Cited by 699
High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines
Antequera, F., Boyes, J., & Bird, A. (1990) · Cell · doi:10.1016/0092-8674(90)90015-7 · Cited by 699
Metadata
- Authors
- Holliday, R.
- Venue
- Science
- Published
- 1987-10-09
- Volume
- 238
- Issue
- 4824
- Pages
- 163-170
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069713835
- Cited by
- 1,082
- References
- 4
- FWCI
- 19.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holliday, R. (1987). The Inheritance of Epigenetic Defects. Science. https://doi.org/10.1126/science.3310230
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
