The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B
Open accessAbstract
Human immunodeficiency virus type 1 (HIV-1) vpr inhibits the replication of tumor cell lines and peripheral blood mononuclear cells. Here it is demonstrated that expression of vpr, either in the context of a provirus or from an independent genetic element, induces a discrete cell cycle arrest, with cells containing 4N DNA. Low cyclin B-associated kinase activity, as well as the status of p34cdc2 and cdc25C phosphorylation, indicates that the cascade of reactions which drives the cell into mitosis has not been initiated. The phosphatase inhibitor okadaic acid releases the block, suggesting that Vpr perturbs upstream regulatorsof the G2-M transition. These studies demonstrate that HIV-1 vpr has profound effects on the cellular factors which control entry into mitosis and indicate vpr's potential contribution to the cellular pathology associated with HIV-1 infection.
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Structural biology of HIV 1 1Edited by P. E. Wright
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HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
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Metadata
- Authors
- Re, F., Braaten, D., Franke, E. K., & Luban, J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1995-11
- Volume
- 69
- Issue
- 11
- Pages
- 6859-6864
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2098625990
- Cited by
- 375
- References
- 40
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Re, F., Braaten, D., Franke, E. K., & Luban, J. (1995). Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. Journal of Virology. https://doi.org/10.1128/jvi.69.11.6859-6864.1995
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