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E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element
Abstract
Human papillomavirus type 11 (HPV-11) and HPV-16 contain an E5 gene that can induce c-fos gene expression in mouse fibroblasts. This study investigated the human c-fos promoter characteristics by mapping the c-fos promoter sequence with several deletion and point mutants that confer responsiveness to E5 of HPV-11 or HPV-16. The mutant studies show that NF1 binding sequences within the c-fos promoter were crucial for the induction of the c-fos gene by E5, and the gel shift assay study suggested that E5 of both HPV-11 and HPV-16 is associated, perhaps indirectly, with this NF1 element in the transactivation of the human c-fos promoter. Using an inducible system, we demonstrate that increased induction of the HPV-11 E5 gene in cells led to increased transactivation of the NF1 element. In addition, the transactivating activity of a series of HPV-11 E5 mutants on the NF1 element had a strong correlation with their respective transforming activities.
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In the citing paper
“ultimately leading to the increased transcription of transcriptional factor AP-1 (activating protein 1), which is composed of c-fos and c-jun and is responsible for promoting the cell cycle [224,225]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [225]
In the citing paper
“As HPV has an enhancer that contains AP-1-binding sites”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [225]
Citations
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Chen, S. L., Lin, Y. K., Li, L. Y., Tsao, Y. P., Lo, H. Y., Wang, W. B., & Tsai, T. C.
- Affiliations
- Department of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1996-12
- Volume
- 70
- Issue
- 12
- Pages
- 8558-8563
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 22
- References
- 0
- Language
- en
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element. https://app.cochat.ai/papers/10.1128/jvi.70.12.8558-8563.1996
- The paper
- Chen, S. L., Lin, Y. K., Li, L. Y., Tsao, Y. P., Lo, H. Y., Wang, W. B., & Tsai, T. C. (1996). E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element. Journal of Virology. https://doi.org/10.1128/jvi.70.12.8558-8563.1996
