The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
Open accessAbstract
The chemokine receptor CCR5 acts as an essential cofactor for cell entry by macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains, whereas CXCR4 acts as an essential cofactor for T-cell-line-adapted strains. We demonstrated that the specific amino acids in the V3 loop of the HIV-1 envelope protein that determine cellular tropism also regulate chemokine coreceptor preference for cell entry by the virus. Further, a strong correlation was found between HIV-1 strains classified as syncytium inducing in standard assays and those using CXCR4 as a coreceptor. These data support the hypothesis that progressive adaptation to additional coreceptors is a key molecular basis for HIV-1 phenotypic evolution in vivo.
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Cites
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Cited by
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
Berger, E. A., Murphy, P. M., & Farber, J. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.657 · Cited by 2,180
Human immunodeficiency virus type 2
Reeves, J. D., & Doms, R. W. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-6-1253 · Cited by 369
Metadata
- Authors
- Speck, R. F., Wehrly, K., Platt, E. J., Atchison, R. E., Charo, I. F., Kabat, D., Chesebro, B., & Goldsmith, M. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1997-09
- Volume
- 71
- Issue
- 9
- Pages
- 7136-7139
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1923928177
- Cited by
- 275
- References
- 31
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Speck, R. F., Wehrly, K., Platt, E. J., Atchison, R. E., Charo, I. F., Kabat, D., Chesebro, B., & Goldsmith, M. A. (1997). Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop. Journal of Virology. https://doi.org/10.1128/jvi.71.9.7136-7139.1997
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