The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1
Abstract
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line-tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.
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Cites
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G., & Engleman, E. G. (1987) · Cell · doi:10.1016/0092-8674(87)90542-3 · Cited by 627
Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism
McClure, M. O., Marsh, M., & Weiss, R. A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02839.x · Cited by 295
Cited by
Wyatt, R., Moore, J., Accola, M., Desjardin, E., Robinson, J., & Sodroski, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5723-5733.1995 · Cited by 417
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311669110 · Cited by 344
Fouchier, R. A. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.15.4531 · Cited by 339
HIV-infected T cells are migratory vehicles for viral dissemination
Murooka, T. T., Deruaz, M., Marangoni, F., Vrbanac, V. D., Seung, E., von Andrian, U. H., Tager, A. M., Luster, A. D., & Mempel, T. R. (2012) · Nature · doi:10.1038/nature11398 · Cited by 322
Speck, R. F., Wehrly, K., Platt, E. J., Atchison, R. E., Charo, I. F., Kabat, D., Chesebro, B., & Goldsmith, M. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.7136-7139.1997 · Cited by 275
Metadata
- Authors
- Hwang, S. S., Boyle, T. J., Lyerly, H. K., & Cullen, B. R.
- Venue
- Science
- Published
- 1991-07-05
- Volume
- 253
- Issue
- 5015
- Pages
- 71-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069407559
- Cited by
- 870
- References
- 2
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1. https://app.cochat.ai/papers/10.1126/science.1905842
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- Hwang, S. S., Boyle, T. J., Lyerly, H. K., & Cullen, B. R. (1991). Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1. Science. https://doi.org/10.1126/science.1905842
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
