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Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus
Open accessAbstract
The glycoproteins expressed by a Zaire species of Ebola virus were analyzed for cleavage, oligomerization, and other structural properties to better define their functions. The 50- to 70-kDa secreted and 150-kDa virion/structural glycoproteins (SGP and GP, respectively), which share the 295 N-terminal residues, are cleaved near the N terminus by signalase. A second cleavage event, occurring in GP at a multibasic site (RRTRR↓) that is likely mediated by furin, results in two glycoproteins (GP1 and GP2) linked by disulfide bonding. This furin cleavage site is present in the same position in the GPs of all Ebola viruses (R[R/K]X[R/K]R↓), and one is predicted for Marburg viruses (R[R/K]KR↓), although in a different location. Based on the results of cross-linking studies, we were able to determine that Ebola virion peplomers are composed of trimers of GP1-GP2 heterodimers and that aspects of their structure are similar to those of retroviruses, paramyxoviruses, and influenza viruses. We also determined that SGP is secreted from infected cells almost exclusively in the form of a homodimer that is joined by disulfide bonding.
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Cited by
Mühlberger, E., Weik, M., Volchkov, V. E., Klenk, H.-D., & Becker, S. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2333-2342.1999 · Cited by 486
Antibody-Dependent Enhancement of Virus Infection and Disease
Tirado, S. M. C., & Yoon, K.-J. (2003) · Viral Immunology · doi:10.1089/088282403763635465 · Cited by 313
Bray, M., & Geisbert, T. W. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.02.018 · Cited by 265
Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.033 · Cited by 212
Hastie, K. M., Salie, Z. L., Ke, Z., Halfmann, P. J., DeWald, L. E., McArdle, S., Grinyó, A., Davidson, E., Schendel, S. L., Hariharan, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56452-2 · Cited by 9
Metadata
- Authors
- Sanchez, A., Yang, Z.-Y., Xu, L., Nabel, G. J., Crews, T., & Peters, C. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-08
- Volume
- 72
- Issue
- 8
- Pages
- 6442-6447
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2147679296
- Cited by
- 235
- References
- 0
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Sanchez, A., Yang, Z.-Y., Xu, L., Nabel, G. J., Crews, T., & Peters, C. J. (1998). Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus. Journal of Virology. https://doi.org/10.1128/jvi.72.8.6442-6447.1998
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