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Cited by 204HIV Research and TreatmentT-cell and B-cell ImmunologyHIV-related health complications and treatments

Gastrointestinal T Lymphocytes Retain High Potential for Cytokine Responses but Have Severe CD4+T-Cell Depletion at All Stages of Simian Immunodeficiency Virus Infection Compared to Peripheral Lymphocytes

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Smit-McBride, Zeljka, Mattapallil, Joseph J., McChesney, Michael, Ferrick, David, Dandekar, Satya·1998·Journal of Virology
DOI 10.1128/jvi.72.8.6646-6656.1998PMC PMC109855
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Abstract

Gastrointestinal complications in human immunodeficiency virus (HIV) infection are indicative of impaired intestinal mucosal immune system. We used simian immunodeficiency virus (SIV)-infected rhesus macaques as an animal model for HIV to determine pathogenic effects of SIV on intestinal T lymphocytes. Intestinal CD4+T-cell depletion and the potential for cytokine responses were examined during SIV infection and compared with results for lymphocytes from lymph nodes and blood. Flow cytometric analysis demonstrated severe depletion of CD4+CD8−single-positive T cells and CD4+CD8+double-positive T cells in intestinal lamina propria lymphocytes (LPL) and intraepithelial lymphocytes (IEL) during primary SIV infection which persisted through the entire course of SIV infection. In contrast, CD4+T-cell depletion was gradual in peripheral lymph nodes and blood. Flow cytometric analysis of intracellular gamma interferon (IFN-γ) and interleukin-4 (IL-4) production following short-term mitogenic activation revealed that LPL retained same or higher capacity for IFN-γ production in all stages of SIV infection compared to uninfected controls, whereas peripheral blood mononuclear cells displayed a gradual decline. The CD8+T cells were the major producers of IFN-γ. There was no detectable change in the frequency of IL-4-producing cells in both LPL and peripheral blood mononuclear cells. Thus, severe depletion of CD4+LPL and IEL in primary SIV infection accompanied by altered cytokine responses may reflect altered T-cell homeostasis in intestinal mucosa. This could be a mechanism of SIV-associated enteropathy and viral pathogenesis. Dynamic changes in intestinal T lymphocytes were not adequately represented in peripheral lymph nodes or blood.

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  • Peripheral blood contains only 2-5% of all lymphocytes, while lungs and gastrointestinal mucosa harbour up to 90% of the body's lymphocytes.

    “Moreover, peripheral blood contains just 2-5% of all lymphocytes, while the lungs and gastrointestinal mucosa harbour up to 90% of the body's lymphocytes (Cerf-Bensussan and Guy-Grand, 1991;Smit-McBride et al., 1998).”

    From Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 <sup>+</sup> effector memory T‐cells (2010) · cites this paper as Smit-McBride et al., 1998

    The Abstract states that peripheral blood contains 2–5% of total lymphocytes and that the gastrointestinal tract harbors over 90%. It does not mention the lungs, and its figure is “over 90%,” rather than “up to 90%.” (LLM, conf=0.85)

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Authors
Smit-McBride, Z., Mattapallil, J. J., McChesney, M., Ferrick, D., & Dandekar, S.
Affiliations
  • <!--label omitted: 1-->Department of Internal Medicine, Division of Infectious Diseases,1
  • <!--label omitted: 2-->California Regional Research Primate Center,2 and
  • University of California, Davis (US)
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
1998-08
Volume
72
Issue
8
Pages
6646-6656
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.72.8.6646-6656.1998
PMC
PMC109855
OpenAlex
W1522340644
Cited by
204
References
1
Citations by year
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FWCI
2.00
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK43183, R01DK043183)
  • National Center for Research Resources (P51RR000169, NCRR00169)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Keywords
simian immunodeficiency virus, SIV infection, intraepithelial lymphocytes, lamina propria lymphocytes, CD4+CD8+ double-positive T cells, cytokine response, intestinal mucosal immunity, rhesus monkeys, CD8+ T cells, T cell homeostasis
MeSH terms
Animals, Flow Cytometry, Humans, Interferon-gamma, Intestinal Mucosa, Intracellular Fluid, Jejunum, Leukocytes, Mononuclear, Lymph Nodes, Lymphocyte Depletion, Macaca mulatta, Simian Immunodeficiency Virus, CD4-Positive T-Lymphocytes, Interleukin-4, Simian Acquired Immunodeficiency Syndrome, CD8-Positive T-Lymphocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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