Cited by 259Evolution and Genetic DynamicsViral Infections and Immunology ResearchGenomics and Phylogenetic Studies

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Evidence of Recombination among Enteroviruses

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Santti, Juhana, Hyypiä, Timo, Kinnunen, Leena, Salminen, Mika·1999·Journal of Virology

DOI 10.1128/jvi.73.10.8741-8749.1999PMC PMC112895

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Abstract

Human enteroviruses consist of more than 60 serotypes, reflecting a wide range of evolutionary divergence. They have been genetically classified into four clusters on the basis of sequence homology in the coding region of the single-stranded RNA genome. To explore further the genetic relationships between human enteroviruses and to characterize the evolutionary mechanisms responsible for variation, previously sequenced genomes were subjected to detailed comparison. Bootstrap and genetic similarity analyses were used to systematically scan the alignments of complete genomic sequences. Bootstrap analysis provided evidence from an early recombination event at the junction of the 5′ noncoding and coding regions of the progenitors of the current clusters. Analysis within the genetic clusters indicated that enterovirus prototype strains include intraspecies recombinants. Recombination breakpoints were detected in all genomic regions except the capsid protein coding region. Our results suggest that recombination is a significant and relatively frequent mechanism in the evolution of enterovirus genomes.

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Authors: Santti, J., Hyypiä, T., Kinnunen, L., & Salminen, M.
Affiliations: University of Turku (FI)
MediCity Research Laboratory and Department of Virology, University of Turku, FIN-20520 Turku,1
Department of Epidemiology and Health Promotion3 and
HIV Laboratory, Department of Infectious Disease Epidemiology,4National Public Health Institute, FIN-00300 Helsinki, Finland
ORCID: Kinnunen, Leena
Salminen, Mika
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1999-10
Volume: 73
Issue: 10
Pages: 8741-8749
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.73.10.8741-8749.1999
PMC: PMC112895
OpenAlex: W2130710544
Cited by: 259
References: 44
Citations by year: 2026: 6 · 2025: 5 · 2024: 16 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 16 · 2013: 14 · 2012: 16
FWCI: 3.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: human enteroviruses, genetic recombination, viral evolution, enterovirus serotypes, recombination breakpoints, 5' untranslated region, single-stranded RNA genome, capsid protein, genetic groups
MeSH terms: Enterovirus, Humans, Recombination, Genetic, Genome, Viral, Evolution, Molecular

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Evidence of Recombination among Enteroviruses

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