The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Neuroinvasion by Human Respiratory Coronaviruses
Open accessAbstract
Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain autopsy samples. Very stringent reverse transcription-PCR with two primer pairs for both viral strains (229E and OC43), combined with Southern hybridization, was performed on samples from 90 coded donors with various neurological diseases (39 with MS and 26 with other neurological diseases) or normal controls (25 patients). We report that 44% (40 of 90) of donors were positive for 229E and that 23% (21 of 90) were positive for OC43. A statistically significant higher prevalence of OC43 in MS patients (35.9%; 14 of 39) than in controls (13.7%; 7 of 51) was observed. Sequencing of nucleocapsid protein (N) gene amplicons revealed point mutations in OC43, some consistently found in three MS patient brains and one normal control but never observed in laboratory viruses. In situ hybridization confirmed the presence of viral RNA in brain parenchyma, outside blood vessels. The presence of HCoV in human brains is consistent with neuroinvasion by these respiratory pathogens. Further studies are needed to distinguish between opportunistic and disease-associated viral presence in human brains.
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Cites
In situ hybridization; a practical approach
(1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90093-t · Cited by 1,220
The Molecular Biology of Coronaviruses
Lai, M. M. C., & Cavanagh, D. (1997) · Advances in Virus Research · doi:10.1016/s0065-3527(08)60286-9 · Cited by 1,143
Fujinami, R. S., & Oldstone, M. B. A. (1985) · Science · doi:10.1126/science.2414848 · Cited by 944
A full genome search in multiple sclerosis
Ebers, G. C., Kukay, K., Bulman, D. E., Sadovnick, A. D., Rice, G., Anderson, C., Armstrong, H., Cousin, K., Bell, R. B., Hader, W., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-472 · Cited by 659
Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.
Challoner, P. B., Smith, K. T., Parker, J. D., MacLeod, D. L., Coulter, S. N., Rose, T. M., Schultz, E. R., Bennett, J. L., Garber, R. L., & Chang, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7440 · Cited by 618
CLINICAL VIRAL INFECTIONS AND MULTIPLE SCLEROSIS
SIBLEY, W. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92801-6 · Cited by 594
Epidemiologic evidence for multiple sclerosis as an infection
Kurtzke, J. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.382 · Cited by 472
Influence of infection on exacerbations of multiple sclerosis
Panitch, H. S. (1994) · Annals of Neurology · doi:10.1002/ana.410360709 · Cited by 276
Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study
Andersen, O., Lygner, P.-E., Bergstr�m, T., Andersson, M., & Vablne, A. (1993) · Journal of Neurology · doi:10.1007/bf00867354 · Cited by 265
Viral particles induce Ia antigen expression on astrocytes
Massa, P. T., Dörries, R., & ter Meulen, V. (1986) · Nature · doi:10.1038/320543a0 · Cited by 241
Cited by
Meinhardt, J., Radke, J., Dittmayer, C., Franz, J., Thomas, C., Mothes, R., Laue, M., Schneider, J., Brünink, S., Greuel, S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00758-5 · Cited by 1,458
Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology · doi:10.1128/jvi.00737-08 · Cited by 1,293
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048
Self-citationTroyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964
Zubair, A. S., McAlpine, L. S., Gardin, T., Farhadian, S., Kuruvilla, D. E., & Spudich, S. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2065 · Cited by 923
Metadata
- Authors
- Arbour, N., Day, R., Newcombe, J., & Talbot, P. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-10
- Volume
- 74
- Issue
- 19
- Pages
- 8913-8921
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2162063510
- Cited by
- 522
- References
- 51
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Arbour, N., Day, R., Newcombe, J., & Talbot, P. J. (2000). Neuroinvasion by Human Respiratory Coronaviruses. Journal of Virology. https://doi.org/10.1128/jvi.74.19.8913-8921.2000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
