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Evolutionary Relationships of Endemic/Epidemic and Sylvatic Dengue Viruses
Open accessAbstract
Endemic/epidemic dengue viruses (DEN) that are transmitted among humans by the mosquito vectors Aedes aegypti and Aedes albopictus are hypothesized to have evolved from sylvatic DEN strains that are transmitted among nonhuman primates in West Africa and Malaysia by other Aedes mosquitoes. We tested this hypothesis with phylogenetic studies using envelope protein gene sequences of both endemic/epidemic and sylvatic strains. The basal position of sylvatic lineages of DEN-1, -2, and -4 suggested that the endemic/epidemic lineages of these three DEN serotypes evolved independently from sylvatic progenitors. Time estimates for evolution of the endemic/epidemic forms ranged from 100 to 1,500 years ago, and the evolution of endemic/epidemic forms represents relatively recent events in the history of DEN evolution. Analysis of envelope protein amino acid changes predicted to have accompanied endemic/epidemic emergence suggested a role for domain III in adaptation to new mosquito and/or human hosts.
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Cited by
Dengue: a continuing global threat
Guzman, M. G., Halstead, S. B., Artsob, H., Buchy, P., Farrar, J., Gubler, D. J., Hunsperger, E., Kroeger, A., Margolis, H. S., Martínez, E., et al. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2460 · Cited by 2,082
Self-citationGlobal Spread and Persistence of Dengue
Kyle, J. L., & Harris, E. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.163005 · Cited by 916
Global spread of dengue virus types: mapping the 70 year history
Messina, J. P., Brady, O. J., Scott, T. W., Zou, C., Pigott, D. M., Duda, K. A., Bhatt, S., Katzelnick, L., Howes, R. E., Battle, K. E., et al. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2013.12.011 · Cited by 716
Farajollahi, A., Fonseca, D. M., Kramer, L. D., & Marm Kilpatrick, A. (2011) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2011.08.013 · Cited by 659
Dengue Virus–Mosquito Interactions
Halstead, S. B. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.53.103106.093326 · Cited by 438
Metadata
- Authors
- Wang, E., Ni, H., Xu, R., Barrett, A. D. T., Watowich, S. J., Gubler, D. J., & Weaver, S. C.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-04
- Volume
- 74
- Issue
- 7
- Pages
- 3227-3234
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2147557549
- Cited by
- 445
- References
- 0
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Evolutionary Relationships of Endemic/Epidemic and Sylvatic Dengue Viruses. https://app.cochat.ai/papers/10.1128/jvi.74.7.3227-3234.2000
- The paper
- Wang, E., Ni, H., Xu, R., Barrett, A. D. T., Watowich, S. J., Gubler, D. J., & Weaver, S. C. (2000). Evolutionary Relationships of Endemic/Epidemic and Sylvatic Dengue Viruses. Journal of Virology. https://doi.org/10.1128/jvi.74.7.3227-3234.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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