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An Envelope Glycoprotein of the Human Endogenous Retrovirus HERV-W Is Expressed in the Human Placenta and Fuses Cells Expressing the Type D Mammalian Retrovirus Receptor
Open accessAbstract
A new human endogenous retrovirus (HERV) family, termed HERV-W, was recently described (J.-L. Blond, F. Besème, L. Duret, O. Bouton, F. Bedin, H. Perron, B. Mandrand, and F. Mallet, J. Virol. 73:1175–1185, 1999). HERV-W mRNAs were found to be specifically expressed in placenta cells, and an env cDNA containing a complete open reading frame was recovered. In cell-cell fusion assays, we demonstrate here that the product of the HERV-W env gene is a highly fusogenic membrane glycoprotein. Transfection of an HERV-W Env expression vector in a panel of cell lines derived from different species resulted in formation of syncytia in primate and pig cells upon interaction with the type D mammalian retrovirus receptor. Moreover, envelope glycoproteins encoded by HERV-W were specifically detected in placenta cells, suggesting that they may play a physiological role during pregnancy and placenta formation.
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Cites
Boller, K., König, H., Sauter, M., Mueller-Lantzsch, N., Löwer, R., Löwer, J., & Kurth, R. (1993) · Virology · doi:10.1006/viro.1993.1487 · Cited by 188
Cited by
Maltepe, E., & Fisher, S. J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125620 · Cited by 592
A comparison of placental development and endocrine functions between the human and mouse model
Malassine, A., Frendo, J. L., & Evain-Brion, D. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg043 · Cited by 476
Paleovirology of ‘ syncytins ’, retroviral env genes exapted for a role in placentation
Lavialle, C., Cornelis, G., Dupressoir, A., Esnault, C., Heidmann, O., Vernochet, C., & Heidmann, T. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0507 · Cited by 413
Antony, J. M., van Marle, G., Opii, W., Butterfield, D. A., Mallet, F., Yong, V. W., Wallace, J. L., Deacon, R. M., Warren, K., & Power, C. (2004) · Nature Neuroscience · doi:10.1038/nn1319 · Cited by 388
Self-citationThe Evolutionary Dynamics of Human Endogenous Retroviral Families
Bannert, N., & Kurth, R. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115700 · Cited by 371
Metadata
- Authors
- Blond, J.-L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F., & Cosset, F.-L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-04
- Volume
- 74
- Issue
- 7
- Pages
- 3321-3329
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2169259354
- Cited by
- 716
- References
- 1
- FWCI
- 34.87
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Blond, J.-L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F., & Cosset, F.-L. (2000). An Envelope Glycoprotein of the Human Endogenous Retrovirus HERV-W Is Expressed in the Human Placenta and Fuses Cells Expressing the Type D Mammalian Retrovirus Receptor. Journal of Virology. https://doi.org/10.1128/jvi.74.7.3321-3329.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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