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Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate
Open accessAbstract
Using pseudoinfection of cell lines, we demonstrate that cell surface heparan sulfate is required for infection by human papillomavirus type 16 (HPV-16) and HPV-33 pseudovirions. Pseudoinfection was inhibited by heparin but not dermatan or chondroitin sulfate, reduced by reducing the level of surface sulfation, and abolished by heparinase treatment. Carboxy-terminally deleted HPV-33 virus-like particles still bound efficiently to heparin. The kinetics of postattachment neutralization by antiserum or heparin indicated that pseudovirions were shifted on the cell surface from a heparin-sensitive into a heparin-resistant mode of binding, possibly involving a secondary receptor. Alpha-6 integrin is not a receptor for HPV-33 pseudoinfection.
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Citations
Cited by
Human papillomavirus and cervical cancer
Burd, E. M. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.1-17.2003 · Cited by 2,420
The Biology and Life-Cycle of Human Papillomaviruses
Doorbar, J., Quint, W., Banks, L., Bravo, I. G., Stoler, M., Broker, T. R., & Stanley, M. A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.06.083 · Cited by 1,528
Carrageenan is a potent inhibitor of papillomavirus infection
Buck, C. B., Thompson, C. D., Roberts, J. N., Müller, M., Lowy, D. R., & Schiller, J. T. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020069 · Cited by 497
Current understanding of the mechanism of HPV infection
Schiller, J. T., Day, P. M., & Kines, R. C. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.04.004 · Cited by 332
Schelhaas, M., Shah, B., Holzer, M., Blattmann, P., Kühling, L., Day, P. M., Schiller, J. T., & Helenius, A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002657 · Cited by 295
Metadata
- Authors
- Giroglou, T., Florin, L., Schäfer, F., Streeck, R. E., & Sapp, M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2001-02
- Volume
- 75
- Issue
- 3
- Pages
- 1565-1570
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2128681927
- Cited by
- 574
- References
- 0
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Giroglou, T., Florin, L., Schäfer, F., Streeck, R. E., & Sapp, M. (2001). Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate. Journal of Virology. https://doi.org/10.1128/jvi.75.3.1565-1570.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
