The DOI matches its Crossref record.
Pre- and Postexposure Prophylaxis of Ebola Virus Infection in an Animal Model by Passive Transfer of a Neutralizing Human Antibody
Open accessAbstract
A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.
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Citations
Cited by
Antibodies, viruses and vaccines
Burton, D. R. (2002) · Nature Reviews Immunology · doi:10.1038/nri891 · Cited by 637
Self-citation
Metadata
- Authors
- Parren, P. W. H. I., Geisbert, T. W., Maruyama, T., Jahrling, P. B., & Burton, D. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-06-15
- Volume
- 76
- Issue
- 12
- Pages
- 6408-6412
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2162730915
- Cited by
- 204
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Pre- and Postexposure Prophylaxis of Ebola Virus Infection in an Animal Model by Passive Transfer of a Neutralizing Human Antibody. https://app.cochat.ai/papers/10.1128/jvi.76.12.6408-6412.2002
- The paper
- Parren, P. W. H. I., Geisbert, T. W., Maruyama, T., Jahrling, P. B., & Burton, D. R. (2002). Pre- and Postexposure Prophylaxis of Ebola Virus Infection in an Animal Model by Passive Transfer of a Neutralizing Human Antibody. Journal of Virology. https://doi.org/10.1128/jvi.76.12.6408-6412.2002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
