Antibodies, viruses and vaccines
Abstract
Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases. They probably act, in most cases, by blunting the infection, which is then resolved by cellular immunity. The protective effects of neutralizing antibodies can be achieved not only by neutralization of free virus particles, but also by several activities directed against infected cells. In certain instances, non-neutralizing antibodies contribute to protection. Several viruses, such as HIV, have evolved mechanisms to evade neutralizing-antibody responses, and these viruses present special challenges for vaccine design that are now being tackled.
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Structure-based design of epitopes recognized by template neutralizing antibodies can engineer antigenicity.
“We and others have engineered antigenicity (13-17) through structure-based design of the epitopes recognized by template neutralizing antibodies.”
From Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus (2013) · cites this paper as [13]
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- Authors
- Burton, D. R.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Burton, Dennis R.
- ORCID
- Burton, Dennis R.
- Venue
- Nature Reviews Immunology
- Published
- 2002-09-01
- Volume
- 2
- Issue
- 9
- Pages
- 706-713
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2131859684
- Cited by
- 637
- References
- 85
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 19 · 2023: 22 · 2022: 27 · 2021: 25 · 2020: 26 · 2019: 38 · 2018: 23 · 2017: 28 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 29 · 2012: 28
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- neutralizing antibodies, viral infection, cell-mediated immunity, non-neutralizing antibodies, HIV, antibody escape, vaccine design
- MeSH terms
- Animals, Antibodies, Viral, Antiviral Agents, Humans, Immunity, Cellular, Immunologic Memory, Vaccination, Viral Vaccines, Virus Diseases, Drug Design, HIV-1, HIV Infections
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