Cited by 637Monoclonal and Polyclonal Antibodies ResearchSARS-CoV-2 and COVID-19 ResearchHIV Research and Treatment

Antibodies, viruses and vaccines

Burton, Dennis R.·2002·Nature Reviews Immunology

Abstract

Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases. They probably act, in most cases, by blunting the infection, which is then resolved by cellular immunity. The protective effects of neutralizing antibodies can be achieved not only by neutralization of free virus particles, but also by several activities directed against infected cells. In certain instances, non-neutralizing antibodies contribute to protection. Several viruses, such as HIV, have evolved mechanisms to evade neutralizing-antibody responses, and these viruses present special challenges for vaccine design that are now being tackled.

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Crossref · 10.1038/nri891

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Authors
Burton, D. R.
Affiliations
Scripps Research Institute (US)
Corresponding author
Burton, Dennis R.
Venue
Nature Reviews Immunology
Published
2002-09-01
Volume
2
Issue
9
Pages
706-713
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2131859684
Cited by
637
References
85
Citations by year
2026: 11 · 2025: 19 · 2024: 19 · 2023: 22 · 2022: 27 · 2021: 25 · 2020: 26 · 2019: 38 · 2018: 23 · 2017: 28 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 29 · 2012: 28
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
neutralizing antibodies, viral infection, cell-mediated immunity, non-neutralizing antibodies, HIV, antibody escape, vaccine design
MeSH terms
Animals, Antibodies, Viral, Antiviral Agents, Humans, Immunity, Cellular, Immunologic Memory, Vaccination, Viral Vaccines, Virus Diseases, Drug Design, HIV-1, HIV Infections

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