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C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans
Open accessAbstract
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
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Cited by
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McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D., & Hope, T. J. (2003) · Science · doi:10.1126/science.1084238 · Cited by 707
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Sakurai, Y., Kolokoltsov, A. A., Chen, C.-C., Tidwell, M. W., Bauta, W. E., Klugbauer, N., Grimm, C., Wahl-Schott, C., Biel, M., & Davey, R. A. (2015) · Science · doi:10.1126/science.1258758 · Cited by 555
Self- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503
Yang, Z.-Y., Huang, Y., Ganesh, L., Leung, K., Kong, W.-P., Schwartz, O., Subbarao, K., & Nabel, G. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5642-5650.2004 · Cited by 490
Exotic emerging viral diseases: progress and challenges
Geisbert, T. W., & Jahrling, P. B. (2004) · Nature Medicine · doi:10.1038/nm1142 · Cited by 441
Metadata
- Authors
- Alvarez, C. P., Lasala, F., Carrillo, J., Muñiz, O., Corbí, A. L., & Delgado, R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-07
- Volume
- 76
- Issue
- 13
- Pages
- 6841-6844
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2118364979
- Cited by
- 652
- References
- 0
- FWCI
- 25.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans. https://app.cochat.ai/papers/10.1128/jvi.76.13.6841-6844.2002
- The paper
- Alvarez, C. P., Lasala, F., Carrillo, J., Muñiz, O., Corbí, A. L., & Delgado, R. (2002). C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans. Journal of Virology. https://doi.org/10.1128/jvi.76.13.6841-6844.2002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
