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Cited by 87

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Immunological Aspects of Recombinant Adeno-Associated Virus Delivery to the Mammalian Brain

Mastakov, Mihail Y., Baer, Kristin, Symes, C. Wymond, Leichtlein, Claudia B., Kotin, Robert M., During, Matthew J.·2002·Journal of Virology
DOI 10.1128/jvi.76.16.8446-8454.2002
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Abstract

Recombinant adeno-associated viruses (rAAV) are highly efficient vectors for gene delivery into the central nervous system (CNS). However, host inflammatory and immune responses may play a critical role in limiting the use of rAAV vectors for gene therapy and functional genomic studies in vivo. Here, we evaluated the effect of repeated injections of five rAAV vectors expressing different genetic sequences (coding or noncoding) in a range of combinations into the rat brain. Specifically, we wished to determine whether a specific immune or inflammatory response appeared in response to the vector and/or the transgene protein after repeated injections under conditions of mannitol coinjection. We show that readministration of the same rAAV to the CNS is possible if the interval between the first and second injection is more than 4 weeks. Furthermore, our data demonstrate that rAAV vectors carrying different genetic sequences can be administered at intervals of 2 weeks. Our data therefore suggest that the AAV capsid structure is altered by the vector genetic sequence, such that secondary structures of the single-stranded genome have an impact on the antigenicity of the virus. This study provides guidelines for more rational design of gene transfer studies in the rodent brain and, in addition, suggests the use of repeated administration of rAAV as a viable form of therapy for the treatment of chronic diseases.

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Crossref · 10.1128/jvi.76.16.8446-8454.2002

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11 of 11 references verified0 citation errors · 0 not checkable

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  • The above-normal increase in branching number closer to the cell body is likely the effect of the viral vector.

    “Informatively, this second effect was also observed after AAV9-GFP injections, and thus is likely the effect of the viral vector, as previously described (Mingozzi and High, 2013; Mastakov et al., 2002; Samaranch et al., 2014; Pluvinage and Wyss-Coray, 2017).”

    From The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease (2022) · cites this paper as Mastakov et al., 2002

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Metadata

Authors
Mastakov, M. Y., Baer, K., Symes, C. W., Leichtlein, C. B., Kotin, R. M., & During, M. J.
Affiliations
  • Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
  • Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2002-08-15
Volume
76
Issue
16
Pages
8446-8454
ISSN
  • 0022-538X
  • 1098-5514
DOI
10.1128/jvi.76.16.8446-8454.2002
Cited by
87
References
11
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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