The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Leader of Human Immunodeficiency Virus Type 1 Genomic RNA Harbors an Internal Ribosome Entry Segment That Is Active during the G 2 /M Phase of the Cell Cycle
Open accessAbstract
The 5′ leader of the human immunodeficiency virus type 1 (HIV-1) genomic RNA contains highly structured domains involved in key steps of the viral life cycle. These RNA domains inhibit cap-dependent protein synthesis. Here we report that the HIV-1 5′ leader harbors an internal ribosome entry site (IRES) capable of driving protein synthesis during the G 2 /M cell cycle phase in which cap-dependent initiation is inhibited. The HIV-1 IRES was delineated with bicistronic mRNAs in in vitro and ex vivo assays. The HIV-1 leader IRES spans nucleotides 104 to 336 and partially overlaps the major determinants of genomic RNA packaging. These data strongly suggest that, as for HIV-1 transcription, IRES-mediated translation initiation could play an important role in virus replication during virus-induced G 2 /M cell cycle arrest.
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Cites
Pelletier, J., & Sonenberg, N. (1985) · Cell · doi:10.1016/0092-8674(85)90200-4 · Cited by 610
Self-citationClever, J., Sassetti, C., & Parslow, T. G. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2101-2109.1995 · Cited by 307 · cited 5×
“leukemia virus-based retroviral vector MLV-Plap-HIV-1(1-336)-neo, the HIV-1”
BackgroundMethodInfluentialAbbink, T. E. M., & Berkhout, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210291200 · Cited by 203
Self-citationBerkowitz, R. D., Luban, J., & Goff, S. P. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7190-7200.1993 · Cited by 193 · cited 5×
“leukemia virus-based retroviral vector MLV-Plap-HIV-1(1-336)-neo, the HIV-1”
BackgroundMethodInfluential
Cited by
Cho, P. F., Poulin, F., Cho-Park, Y. A., Cho-Park, I. B., Chicoine, J. D., Lasko, P., & Sonenberg, N. (2005) · Cell · doi:10.1016/j.cell.2005.02.024 · Cited by 267
Self-citationViral IRES RNA structures and ribosome interactions
Kieft, J. S. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.04.007 · Cited by 259
Nair, V. P., Anang, S., Subramani, C., Madhvi, A., Bakshi, K., Srivastava, A., Shalimar, Nayak, B., CT, R. K., & Surjit, M. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005521 · Cited by 257
Host factors exploited by retroviruses
Goff, S. P. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1541 · Cited by 247
Zhao, F., Yu, C.-H., & Liu, Y. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx501 · Cited by 120
“The preparation of translation extract was modified from a protocol previously described (55).”
Method
Metadata
- Authors
- Brasey, A., Lopez-Lastra, M., Ohlmann, T., Beerens, N., Berkhout, B., Darlix, J.-L., & Sonenberg, N.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-04
- Volume
- 77
- Issue
- 7
- Pages
- 3939-3949
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1970006967
- Cited by
- 201
- References
- 4
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Brasey, A., Lopez-Lastra, M., Ohlmann, T., Beerens, N., Berkhout, B., Darlix, J.-L., & Sonenberg, N. (2003). The Leader of Human Immunodeficiency Virus Type 1 Genomic RNA Harbors an Internal Ribosome Entry Segment That Is Active during the G 2 /M Phase of the Cell Cycle. Journal of Virology. https://doi.org/10.1128/jvi.77.7.3939-3949.2003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
