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Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates
Open accessAbstract
The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a “switching” mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP.
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Cited by
RIG-I detects viral genomic RNA during negative-strand RNA virus infection
Rehwinkel, J., Tan, C. P., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.020 · Cited by 585
Self-citationStrand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA
Kawakami, E., Watanabe, T., Fujii, K., Goto, H., Watanabe, S., Noda, T., & Kawaoka, Y. (2011) · Journal of Virological Methods · doi:10.1016/j.jviromet.2010.12.014 · Cited by 288
Common and unique features of viral RNA-dependent polymerases
te Velthuis, A. J. W. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1695-z · Cited by 275
Phosphorylation controls RNA binding and transcription by the influenza virus polymerase
Dawson, A. R., Wilson, G. M., Freiberger, E. C., Mondal, A., Coon, J. J., & Mehle, A. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008841 · Cited by 32
A two-step mechanism for RIG-I activation by influenza virus mvRNAs
Pitré, E., Bisht, K., Remick, K. A., Ghorbani, A., Yewdell, J. W., Elshina, E., & te Velthuis, A. J. W. (2025) · Science Advances · doi:10.1126/sciadv.adw8034 · Cited by 12
Metadata
- Authors
- Vreede, F. T., Jung, T. E., & Brownlee, G. G.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-09
- Volume
- 78
- Issue
- 17
- Pages
- 9568-9572
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2168629186
- Cited by
- 225
- References
- 0
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates. https://app.cochat.ai/papers/10.1128/jvi.78.17.9568-9572.2004
- The paper
- Vreede, F. T., Jung, T. E., & Brownlee, G. G. (2004). Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates. Journal of Virology. https://doi.org/10.1128/jvi.78.17.9568-9572.2004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
