Cited by 284interferon and immune responsesRespiratory viral infections researchVirology and Viral Diseases

Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness

Open access
Lo, Mindy S., Brazas, Robert M., Holtzman, Michael J.·2005·Journal of Virology

Abstract

Respiratory syncytial virus (RSV) subverts the antiviral interferon (IFN) response, but the mechanism for this evasion was unclear. Here we show that RSV preferentially inhibits IFN-α/β signaling by expression of viral NS1 and NS2. Thus, RSV infection or expression of recombinant NS1 and NS2 in epithelial host cells causes a marked decrease in Stat2 levels and the consequent downstream IFN-α/β response. Similarly, NS1/NS2-deficient RSV no longer decreases Stat2 levels or IFN responsiveness. RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion.

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Crossref · 10.1128/jvi.79.14.9315-9319.2005

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26 of 26 references verified0 citation errors · 0 not checkable

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  • Parainfluenza viruses inhibit IRF-3 activation.

    “IRF-3 activation is inhibited by RSV (273) and parainfluenza viruses (165).”
  • Parainfluenza viruses target the phosphorylation of IRF3 specifically, by encoding V accessory proteins which act as substrates for the kinases TBK1 and IKK-ι/ɛ.

    “In contrast, parainfluenza viruses target the phosphorylation of IRF3 specifically, by encoding V accessory proteins which act as substrates for the kinases TBK1 and IKK-ι/ɛ.”

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Authors
Lo, M. S., Brazas, R. M., & Holtzman, M. J.
Affiliations
  • Departments of Medicine
  • Duke Medical Center (US)
  • Washington University in St. Louis (US)
Corresponding author
Holtzman, Michael J.
Venue
Journal of Virology
Published
2005-07
Volume
79
Issue
14
Pages
9315-9319
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2051874642
Cited by
284
References
26
Citations by year
2026: 13 · 2025: 12 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 13 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 17 · 2013: 11 · 2012: 14
FWCI
6.50
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
respiratory syncytial virus, NS1 protein, NS2, STAT2, interferon-alpha/beta signaling, interferon antagonism, viral immune evasion, host range, epithelial cells, antiviral response
MeSH terms
Cell Line, DNA-Binding Proteins, Humans, Signal Transduction, Trans-Activators, Interferon-alpha, Interferon-beta, Viral Nonstructural Proteins, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, STAT2 Transcription Factor

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