Cited by 284interferon and immune responsesRespiratory viral infections researchVirology and Viral Diseases

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Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness

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Lo, Mindy S., Brazas, Robert M., Holtzman, Michael J.·2005·Journal of Virology

DOI 10.1128/jvi.79.14.9315-9319.2005PMC PMC1168759

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Abstract

Respiratory syncytial virus (RSV) subverts the antiviral interferon (IFN) response, but the mechanism for this evasion was unclear. Here we show that RSV preferentially inhibits IFN-α/β signaling by expression of viral NS1 and NS2. Thus, RSV infection or expression of recombinant NS1 and NS2 in epithelial host cells causes a marked decrease in Stat2 levels and the consequent downstream IFN-α/β response. Similarly, NS1/NS2-deficient RSV no longer decreases Stat2 levels or IFN responsiveness. RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion.

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Authors: Lo, M. S., Brazas, R. M., & Holtzman, M. J.
Affiliations: Departments of Medicine
Duke Medical Center (US)
Washington University in St. Louis (US)
Corresponding author: Holtzman, Michael J.
ORCID: Lo, Mindy S.
Holtzman, Michael J.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2005-07
Volume: 79
Issue: 14
Pages: 9315-9319
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.79.14.9315-9319.2005
PMC: PMC1168759
OpenAlex: W2051874642
Cited by: 284
References: 26
Citations by year: 2026: 13 · 2025: 12 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 13 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 17 · 2013: 11 · 2012: 14
FWCI: 6.50
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: respiratory syncytial virus, NS1 protein, NS2, STAT2, interferon-alpha/beta signaling, interferon antagonism, viral immune evasion, host range, epithelial cells, antiviral response
MeSH terms: Cell Line, DNA-Binding Proteins, Humans, Signal Transduction, Trans-Activators, Interferon-alpha, Interferon-beta, Viral Nonstructural Proteins, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, STAT2 Transcription Factor

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Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness

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