Holtzman, Michael J.

Potently neutralizing and protective human antibodies against SARS-CoV-2

Zost, S. J., Gilchuk, P., Case, J. B., Binshtein, E., Chen, R. E., Nkolola, J. P., Schäfer, A., Reidy, J. X., Trivette, A., Nargi, R. S., et al. (2020) · Nature

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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Winkler, E. S., Bailey, A. L., Kafai, N. M., Nair, S., McCune, B. T., Yu, J., Fox, J. M., Chen, R. E., Earnest, J. T., Keeler, S. P., et al. (2020) · Nature Immunology

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The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Steed, A. L., Christophi, G. P., Kaiko, G. E., Sun, L., Goodwin, V. M., Jain, U., Esaulova, E., Artyomov, M. N., Morales, D. J., Holtzman, M. J., et al. (2017) · Science

interferon and immune responsesGut microbiota and health

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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Kim, E. Y., Battaile, J. T., Patel, A. C., You, Y., Agapov, E., Grayson, M. H., Benoit, L. A., Byers, D. E., Alevy, Y., Tucker, J., et al. (2008) · Nature Medicine

Asthma and respiratory diseasesIL-33, ST2, and ILC Pathways

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Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

Byers, D. E., Alexander-Brett, J., Patel, A. C., Agapov, E., Dang-Vu, G., Jin, X., Wu, K., You, Y., Alevy, Y., Girard, J.-P., et al. (2013) · Journal of Clinical Investigation

IL-33, ST2, and ILC PathwaysChronic Obstructive Pulmonary Disease (COPD) Research

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Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness

Lo, M. S., Brazas, R. M., & Holtzman, M. J. (2005) · Journal of Virology

interferon and immune responsesRespiratory viral infections research

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Stat1 Depends on Transcriptional Synergy with Sp1

Look, D. C., Pelletier, M. R., Tidwell, R. M., Roswit, W. T., & Holtzman, M. J. (1995) · Journal of Biological Chemistry

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Kober, D. L., Alexander-Brett, J. M., Karch, C. M., Cruchaga, C., Colonna, M., Holtzman, M. J., & Brett, T. J. (2016) · eLife

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

Wu, K., Byers, D. E., Jin, X., Agapov, E., Alexander-Brett, J., Patel, A. C., Cella, M., Gilfilan, S., Colonna, M., Kober, D. L., et al. (2015) · Journal of Experimental Medicine

Inflammation biomarkers and pathwaysImmune Response and Inflammation

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Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., et al. (2020) · Neuron

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Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life

Sumino, K., Tucker, J., Shahab, M., Jaffee, K. F., Visness, C. M., Gern, J. E., Bloomberg, G. R., & Holtzman, M. J. (2012) · Journal of Allergy and Clinical Immunology

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