Cited by 304Respiratory viral infections researchVirology and Viral DiseasesInfluenza Virus Research Studies

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Infection of Ciliated Cells by Human Parainfluenza Virus Type 3 in an In Vitro Model of Human Airway Epithelium

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Zhang, Liqun, Bukreyev, Alexander, Thompson, Catherine I., Watson, Brandy, Peeples, Mark E., Collins, Peter L., Pickles, Raymond J.·2005·Journal of Virology

DOI 10.1128/jvi.79.2.1113-1124.2005PMC PMC538579

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Abstract

We constructed a human recombinant parainfluenza virus type 3 (rPIV3) that expresses enhanced green fluorescent protein (GFP) and used this virus, rgPIV3, to characterize PIV3 infection of an established in vitro model of human pseudostratified mucociliary airway epithelium (HAE). The apical surface of HAE was highly susceptible to rgPIV3 infection, whereas only occasional cells were infected when virus was applied to the basolateral surface. Infection involved exclusively ciliated epithelial cells. There was little evidence of virus-mediated cytopathology and no spread of the virus beyond the ciliated cell types. Infection of ciliated cells by rgPIV3 was sensitive to a neuraminidase specific for α2-6-linked sialic acid residues, but not to a neuraminidase that cleaves α2-3- and α2-8-linked sialic acid residues. This provided evidence that rgPIV3 utilizes α2-6-linked sialic acid residues for initiating infection, a specificity also described for human influenza viruses. The PIV3 fusion (F) glycoprotein was trafficked exclusively to the apical surface of ciliated cells, which also was the site of release of progeny virus. F glycoprotein localized predominately to the membranes of the cilial shafts, suggesting that progeny viruses may bud from cilia per se. The polarized trafficking of F glycoprotein to the apical surface also likely restricts its interaction with neighboring cells and could account for the observed lack of cell-cell fusion. HAE derived from cystic fibrosis patients was not more susceptible to rgPIV3 infection but did exhibit limited spread of virus due to impaired movement of lumenal secretions due to compromised function of the cilia.

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Authors: Zhang, L., Bukreyev, A., Thompson, C. I., Watson, B., Peeples, M. E., Collins, P. L., & Pickles, R. J.
Affiliations: Cystic Fibrosis/Pulmonary Research and Treatment Center
National Institutes of Health (US)
Abigail Wexner Research Institute (US)
University of North Carolina at Chapel Hill (US)
ORCID: Zhang, Liqun
Bukreyev, Alexander
Peeples, Mark E.
Collins, Peter L.
Pickles, Raymond J.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2005-01-15
Volume: 79
Issue: 2
Pages: 1113-1124
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.79.2.1113-1124.2005
PMC: PMC538579
OpenAlex: W2159953474
Cited by: 302
References: 50
Citations by year: 2026: 12 · 2025: 12 · 2024: 19 · 2023: 13 · 2022: 16 · 2021: 17 · 2020: 19 · 2019: 17 · 2018: 12 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 15
FWCI: 6.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (P01HL051818, HL 66943-01, HL 51818-09)
Topics: Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Keywords: parainfluenza virus type 3, ciliated epithelial cells, airway epithelium, neuraminidase sensitivity, cell-cell fusion, cystic fibrosis
MeSH terms: Bronchi, Cell Differentiation, Cells, Cultured, Cilia, Epithelial Cells, Heparan Sulfate, Heparitin Sulfate, Humans, Neuraminidase, Parainfluenza Virus 3, Human, Trachea, Viral Proteins, Virus Shedding, N-Acetylneuraminic Acid

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Infection of Ciliated Cells by Human Parainfluenza Virus Type 3 in an In Vitro Model of Human Airway Epithelium

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