Cited by 130T-cell and Retrovirus StudiesRNA Research and SplicingHIV Research and Treatment

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Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus

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Mertz, Jennifer A., Simper, Melissa S., Lozano, Mary M., Payne, Shelley M., Dudley, Jaquelin P.·2005·Journal of Virology

DOI 10.1128/jvi.79.23.14737-14747.2005PMC PMC1287593

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Abstract

Mouse mammary tumor virus (MMTV) has been classified as a simple retrovirus with two accessory genes,dut and sag. Cloned MMTV proviruses carrying a trimethoprim (trim) cassette in the envelope gene were defective for Gag protein production and the nuclear export of unspliced gag-pol RNA. Complementation experiments indicated that a trans-acting product was responsible for the Gag defect of such mutants. Analysis of MMTV-infected cells revealed the presence of a novel, doubly spliced RNA that encodes a putative product of 301 amino acids. Overexpression of cDNA from this RNA increased Gag levels from env mutant proviruses or reporter gene expression from unspliced mRNAs and allowed detection of a 33-kDa protein product, which has been named r egulator of e xport of MMTV m RNA, or Rem. The Rem N terminus has motifs similar to the Rev-like export proteins of complex retroviruses, and mutation of the nuclear localization signal (NLS) abolished RNA export and detection within the nucleus. The Rem C terminus has few identifiable features, but removal of this domain increased Rem-mediated export, suggesting an autoregulatory function. A reporter vector developed from the 3′ end of the MMTV provirus was Rem responsive and required both the presence of the MMTV env-U3 junction and a functional Crm1 pathway. The identification of a third accessory protein from a doubly spliced transcript suggests that MMTV is the first murine complex retrovirus to be documented. Manipulation of the MMTV genome may provide mouse models for human retroviral diseases, such as AIDS.

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Fornerod, M. W. J., Ohno, M., Yoshida, M., & Mattaj, I. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80371-2 · Cited by 2,086
Understanding alternative splicing: towards a cellular code
Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299
Identification of a signal for rapid export of proteins from the nucleus
Wen, W., Meinkotht, J. L., Tsien, R. Y., & Taylor, S. S. (1995) · Cell · doi:10.1016/0092-8674(95)90435-2 · Cited by 1,190
Encyclopedia of virology
Granoff, A., & Webster, R. G. (1999) · Academic Press eBooks · Cited by 782
Retroviral restriction by APOBEC proteins
Harris, R. S., & Liddament, M. T. (2004) · Nature reviews. Immunology · doi:10.1038/nri1489 · Cited by 657
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
Wolff, B., Sanglier, J., & Wang, Y. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90257-x · Cited by 656
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
Segref, A., Sharma, K., Doye, V., Hellwig, A., Huber, J., Lührmann, R., & Hurt, E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3256 · Cited by 528
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence
Malim, M. H., Tiley, L. S., McCarn, D. F., Rusche, J. R., Hauber, J., & Cullen, B. R. (1990) · Cell · doi:10.1016/0092-8674(90)90670-a · Cited by 430
A small element from the Mason-Pfizer monkey virusgenome makes human immunodeficiency virus type 1 expression and replicationRev-independent.
Bray, M., Prasad, S., Dubay, J. W., Hunter, E., Jeang, K. T., Rekosh, D., & Hammarskjöld, M. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1256 · Cited by 425
Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes
Malim, M. H., Hauber, J., Fenrick, R., & Cullen, B. R. (1988) · Nature · doi:10.1038/335181a0 · Cited by 392
Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo
Brennan, C. M., Gallouzi, I., & STEITZ, J. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.1 · Cited by 377
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region
Hadzopoulou-Cladaras, M., Felber, B. K., Cladaras, C., Athanassopoulos, A., Tse, A., & Pavlakis, G. N. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1265-1274.1989 · Cited by 351
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.Preprint
Meyer, B. E., & Malim, M. H. (1994) · Genes & Development · doi:10.1101/gad.8.13.1538 · Cited by 312
Nuclear mRNA export: insights from virology
Cullen, B. R. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00142-7 · Cited by 300
Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus
Saltarelli, M. J., Quérat, G., Konings, D. A. M., Vigne, R., & Clements, J. E. (1990) · Virology · doi:10.1016/0042-6822(90)90303-9 · Cited by 274
Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth
Chan, W., Liu, Q., Borjigin, J., Busch, H., Rennert, O. M., Tease, L. A., & Chan, P. K. (1989) · Biochemistry · doi:10.1021/bi00429a017 · Cited by 270
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Kang, Y., & Cullen, B. R. (1999) · Genes & Development · doi:10.1101/gad.13.9.1126 · Cited by 246
Targeting proteins to membranes: structure of the signal recognition particle
Egea, P. F., Stroud, R. M., & Walter, P. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.03.007 · Cited by 236
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.
Hope, T. J., Huang, X. J., McDonald, D., & Parslow, T. G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7787 · Cited by 226
Transgenic mouse mammary tumor virus superantigen expression prevents viral infection
Golovkina, T. V., Chervonsky, A. V., Dudley, J. P., & Ross, S. R. (1992) · Cell · doi:10.1016/0092-8674(92)90227-4 · Cited by 221
Self-citation
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Löwer, R., Tönjes, R. R., Korbmacher, C., Kurth, R., & Löwer, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.141-149.1995 · Cited by 201
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Hanly, S. M., Rimsky, L. T., Malim, M. H., Kim, J. H., Hauber, J., Dodon, M. D., Le, S., Maizel, J. V., Cullen, B. R., & Greene, W. C. (1989) · Genes & Development · doi:10.1101/gad.3.10.1534 · Cited by 195
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TAP binds to the constitutive transport element (CTE) through a novel RNA‐binding motif that is sufficient to promote CTE‐dependent RNA export from the nucleus
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Elder, J. H., Lerner, D. L., Hasselkus-Light, C. S., Fontenot, D. J., Hunter, E., Luciw, P. A., Montelaro, R. C., & Phillips, T. R. (1992) · Journal of Virology · doi:10.1128/jvi.66.3.1791-1794.1992 · Cited by 155
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Retroviral mRNA nuclear export elements regulate protein function and virion assembly
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Signal recognition particle mediates post‐translational targeting in eukaryotes
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Formation of Tap/NXT1 Heterodimers Activates Tap-Dependent Nuclear mRNA Export by Enhancing Recruitment to Nuclear Pore Complexes
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Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.
Shackleford, G. M., & VARMUS, H. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9655 · Cited by 89
Multiple Groups of Endogenous Betaretroviruses in Mice, Rats, and Other Mammals
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Kimura, T., Hashimoto, I., Nagase, T., & Fujisawa, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01076 · Cited by 73
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Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon γ–dependent Production of Virus-neutralizing Antibodies
Purdy, A. E., Case, L. K., Duvall, M. G., Overstrom-Coleman, M., Ioannidis, N. M., Chervonsky, A. V., & Golovkina, T. V. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021499 · Cited by 70
B and T Cells Are Required for Mouse Mammary Tumor Virus Spread Within the Mammary Gland
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Self-citation
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Berger, J., Aepinus, C., Dobrovnik, M., Fleckenstein, B., Hauber, J., & Böhnlein, E. (1991) · Virology · doi:10.1016/0042-6822(91)90992-k · Cited by 43
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Retroviruses 2004: review of the 2004 Cold Spring Harbor Retroviruses Conference.
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Authors: Mertz, J. A., Simper, M. S., Lozano, M. M., Payne, S. M., & Dudley, J. P.
Affiliations: The University of Texas at Austin (US)
Corresponding author: Dudley, Jaquelin P.
ORCID: Mertz, Jennifer A.
Payne, Shelley M.
Dudley, Jaquelin P.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2005-12-15
Volume: 79
Issue: 23
Pages: 14737-14747
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.79.23.14737-14747.2005
PMC: PMC1287593
OpenAlex: W2109377528
Cited by: 130
References: 58
Citations by year: 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 8
FWCI: 1.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: mouse mammary tumor virus, RNA export, nuclear export, Gag protein, accessory genes, nuclear localization signal, murine retrovirus
MeSH terms: Animals, Mammary Tumor Virus, Mouse, RNA, Viral, Viral Proteins, Mice

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Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus

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