InvL, an Invasin-Like Adhesin, Is a Type II Secretion System Substrate Required for Acinetobacter baumannii Uropathogenesis
Open accessPublished version of a preprint
Abstract
While pathogenic Acinetobacter can cause various infections, we recently found that 20% of clinical isolates come from urinary sources. Despite the clinical relevance of Acinetobacter as a uropathogen, few virulence factors involved in urinary tract colonization have been defined.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Bacterial Adhesion and Entry into Host Cells
Pizarro-Cerdá, J., & Cossart, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.012 · Cited by 977 · see citing works
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- Authors
- Jackson-Litteken, C. D., Di Venanzio, G., Le, N.-H., Scott, N. E., Djahanschiri, B., Distel, J. S., Pardue, E. J., Ebersberger, I., & Feldman, M. F.
- Affiliations
- Washington University in St. Louis (US)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
- The University of Melbourne (AU)
- Goethe University Frankfurt (DE)
- Corresponding author
- Feldman, Mario F.
- ORCID
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2022-06-28
- Volume
- 13
- Issue
- 3
- Pages
- e0025822-e0025822
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC9245377
- OpenAlex
- W4281729154
- Cited by
- 38
- References
- 3
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 5 · 2023: 10 · 2022: 1
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI144120, T32AI007172)
- Deutsche Forschungsgemeinschaft (EB-285-2/2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Acinetobacter baumannii, type II secretion system, urinary tract infection, virulence factors, bacterial adhesion, urinary tract colonization
- MeSH terms
- Type II Secretion Systems, Type V Secretion Systems, Acinetobacter Infections, Animals, Urinary Tract Infections, Adhesins, Bacterial, Proteomics, Acinetobacter baumannii
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