The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression
Open accessAbstract
Most of the human genome is transcribed into protein-noncoding RNAs (ncRNAs), including small ncRNAs and long ncRNAs (lncRNAs). Over the past decade, rapidly emerging evidence has increasingly supported the view that lncRNAs serve key regulatory and functional roles in mammal cells. HIV-1 replication relies on various cell functions. To date, while the involvement of host protein factors and microRNAs (miRNAs) in the HIV-1 life cycle has been extensively studied, the relationship between lncRNAs and HIV-1 remains uncharacterized. Here, we have profiled 83 disease-related lncRNAs in HIV-1-infected T cells. We found NEAT1 to be one of several lncRNAs whose expression is changed by HIV-1 infection, and we have characterized its role in HIV-1 replication. We report here that the knockdown of NEAT1 enhances virus production through increased nucleus-to-cytoplasm export of Rev-dependent instability element (INS)-containing HIV-1 mRNAs. IMPORTANCE Long protein-noncoding RNAs (lncRNAs) play roles in regulating gene expression and modulating protein activities. There is emerging evidence that lncRNAs are involved in the replication of viruses. To our knowledge, this report is the first to characterize a role contributed by an lncRNA, NEAT1, to HIV-1 replication. NEAT1 is essential for the integrity of the nuclear paraspeckle substructure. Based on our findings from NEAT1 knockdown, we have identified the nuclear paraspeckle body as another important subcellular organelle for HIV-1 replication.
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Cited by
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Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
Bottini, S., Hamouda-Tekaya, N., Mategot, R., Zaragosi, L.-E., Audebert, S., Pisano, S., Grandjean, V., Mauduit, C., Benahmed, M., Barbry, P., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01126-x · Cited by 89
Xiao, X., Zhu, W., Liao, B., Xu, J., Gu, C., Ji, B., Yao, Y., Peng, L., & Yang, J. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00411 · Cited by 47
Noncoding RNAs in Retrovirus Replication
Duchon, A. A., & Musier-Forsyth, K. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00012-1 · Cited by 1
Metadata
- Authors
- Zhang, Q., Chen, C.-Y., Yedavalli, V. S. R. K., & Jeang, K.-T.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2013-03
- Volume
- 4
- Issue
- 1
- Pages
- e00596-12
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- OpenAlex
- W2158541290
- Cited by
- 389
- References
- 77
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, Q., Chen, C.-Y., Yedavalli, V. S. R. K., & Jeang, K.-T. (2013). NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression. mBio. https://doi.org/10.1128/mbio.00596-12
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