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Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota
Open accessAbstract
UNLABELLED: Cervicovaginal mucus (CVM) can provide a barrier that precludes HIV and other sexually transmitted virions from reaching target cells in the vaginal epithelium, thereby preventing or reducing infections. However, the barrier properties of CVM differ from woman to woman, and the causes of these variations are not yet well understood. Using high-resolution particle tracking of fluorescent HIV-1 pseudoviruses, we found that neither pH nor Nugent scores nor total lactic acid levels correlated significantly with virus trapping in unmodified CVM from diverse donors. Surprisingly, HIV-1 was generally trapped in CVM with relatively high concentrations of d-lactic acid and a Lactobacillus crispatus-dominant microbiota. In contrast, a substantial fraction of HIV-1 virions diffused rapidly through CVM with low concentrations of d-lactic acid that had a Lactobacillus iners-dominant microbiota or significant amounts of Gardnerella vaginalis, a bacterium associated with bacterial vaginosis. Our results demonstrate that the vaginal microbiota, including specific species of Lactobacillus, can alter the diffusional barrier properties of CVM against HIV and likely other sexually transmitted viruses and that these microbiota-associated changes may account in part for the elevated risks of HIV acquisition linked to bacterial vaginosis or intermediate vaginal microbiota. IMPORTANCE: Variations in the vaginal microbiota, especially shifts away from Lactobacillus-dominant microbiota, are associated with differential risks of acquiring HIV or other sexually transmitted infections. However, emerging evidence suggests that Lactobacillus iners frequently colonizes women with recurring bacterial vaginosis, raising the possibility that L. iners may not be as protective as other Lactobacillus species. Our study was designed to improve understanding of how the cervicovaginal mucus barrier against HIV may vary between women along with the vaginal microbiota and led to the finding that the vaginal microbiota, including specific species of Lactobacillus, can directly alter the diffusional barrier properties of cervicovaginal mucus. This work advances our understanding of the complex barrier properties of mucus and highlights the differential protective ability of different species of Lactobacillus, with Lactobacillus crispatus and possibly other species playing a key role in protection against HIV and other sexually transmitted infections. These findings could lead to the development of novel strategies to protect women against HIV.
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“A Lactobacillus crispatus-dominant microbiota has been shown to impede the diffusion of HIV-1 virions, in contrast to the rapid diffusion observed with a Lactobacillus iners-dominant microbiota, or when Gardnerella vaginalis is present in significant amounts (Nunn et al., 2015).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Nunn et al., 2015
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“A L. crispatus-dominated vaginal microbiota produces high concentrations of D-lactate which has been recently shown to increase cervicovaginal mucus viscosity and enhance its viral particle trapping potential (Nunn et al., 2015), and tends to have the least likelihood of viral infections of all CSTs (Borgdorff et al., 2014).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Nunn et al., 2015
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Cites
Vaginal microbiome of reproductive-age women
Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254
Nugent, R. P., Krohn, M. A., & Hillier, S. L. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.2.297-301.1991 · Cited by 3,332
Masters, W. H., & Johnson, V. E. (1966) · Medical Entomology and Zoology · Cited by 3,080
Amsel, R., Totten, P. A., Spiegel, C. A., Chen, K. C. S., Eschenbach, D. A., & Holmes, K. K. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91112-9 · Cited by 2,412
Fadrosh, D. W., Ma, B., Gajer, P., Sengamalay, N., Ott, S., Brotman, R. M., & Ravel, J. (2014) · Microbiome · doi:10.1186/2049-2618-2-6 · Cited by 1,698
Self-citationTemporal Dynamics of the Human Vaginal Microbiota
Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J. M., Schütte, U. M. E., Zhong, X., Koenig, S. S. K., Fu, L., Ma, Z. S., Zhou, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003605 · Cited by 1,583
Micro- and macrorheology of mucus
Lai, S. K., Wang, Y.-Y., Wirtz, D., & Hanes, J. S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.012 · Cited by 1,268
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis
Sewankambo, N. K., Gray, R. H., Wawer, M. J., Paxton, L. A., McNairn, D., Wabwire‐Mangen, F., Serwadda, D., Li, C., Kiwanuka, N., Hillier, S. L., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01063-5 · Cited by 657
Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota
O’Hanlon, D. E., Moench, T. R., & Cone, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080074 · Cited by 548
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 215
Wang, Y.-Y., Schroeder, H. A., Nunn, K. L., Woods, K., Anderson, D. J., Lai, S. K., & Cone, R. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158338 · Cited by 23
The human female urogenital microbiome: complexity in normality
MacIntyre, D. A., Sykes, L., & Bennett, P. R. (2017) · Emerging Topics in Life Sciences · doi:10.1042/etls20170042 · Cited by 22
Tuning Barrier Properties of Biological Hydrogels
Schiller, J. L., & Lai, S. K. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00187 · Cited by 23
The role of vaginal microecology in the cervical cancer
Wei, W., Xie, L., Xia, Q. H., Fu, Y., Liu, F., Ding, D., & Han, F. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15359 · Cited by 22
Landolt, E. F., Mendonça, J. D. C., Behler, A. E., Lumsdaine, S. W., Jafar, T., & Burcham, L. R. (2025) · Infection and Immunity · doi:10.1128/iai.00499-24 · Cited by 26
Farcasanu, M., & Kwon, D. S. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0380-5 · Cited by 21
Pharmaceutical Approaches to HIV Treatment and Prevention
Yavuz, B., Morgan, J. L., Showalter, L., Crakes, K. R., Dandekar, S., Herrera, C., LiWang, P. J., & Kaplan, D. L. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800054 · Cited by 22
Cervicovaginal mucus barrier properties during pregnancy are impacted by the vaginal microbiome
Zierden, H. C., DeLong, K., Zulfiqar, F., Ortiz, J., Laney, V. E. A., Bensouda, S., Hernández, N., Hoang, T., Lai, S. K., Hanes, J. S., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1015625 · Cited by 16
Loeper, N., Graspeuntner, S., & Rupp, J. (2018) · Microbes and Infection · doi:10.1016/j.micinf.2018.02.003 · Cited by 17
Zhong, L., Zheng, J., Wang, Z., Lin, L., Cong, Q., & Qiao, L. (2024) · Talanta · doi:10.1016/j.talanta.2024.126839 · Cited by 14
Microdroplet co-cultivation and interaction characterization of human vaginal bacteria
Jackman, C. M., Deans, K. W., Forney, L. J., & Lin, X. N. (2019) · Integrative Biology · doi:10.1093/intbio/zyz006 · Cited by 14
Cervicovaginal Microbiota Predicts Neisseria gonorrhoeae Clinical Presentation
Lovett, A., Seña, A. C., Macintyre, A. N., Sempowski, G. D., Duncan, J. A., & Waltmann, A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.790531 · Cited by 16
Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds
Schiller, J. L., Fogle, M. M., Bussey, O. K., Kissner, W. J., Hill, D. B., & Lai, S. K. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.03.002 · Cited by 14
Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review
Papamentzelopoulou, M., & Pitiriga, V. C. (2025) · Pathogens · doi:10.3390/pathogens14030293 · Cited by 16
Introducing Lu-1, a Novel Lactobacillus jensenii Phage Abundant in the Urogenital Tract
Miller-Ensminger, T., Mormando, R., Maskeri, L., Shapiro, J. W., Wolfe, A. J., & Putonti, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234159 · Cited by 13
Gustin, A. T., Cromarty, R. T., Schifanella, L., & Klatt, N. R. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101482 · Cited by 16
The Vaginal Virome in Women’s Health and Disease
Orton, K. L., & Monaco, C. L. (2025) · Microorganisms · doi:10.3390/microorganisms13020431 · Cited by 13
Tyssen, D. P., Hearps, A. C., Guntur, K., Masson, L., Cook, S., Moulton, S. E., Ravel, J., Bradshaw, C. S., Ayehunie, S., & Tachedjian, G. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.915948 · Cited by 12
Impact of HIV on the human gut microbiota: Challenges and perspectives
Dubourg, G. (2016) · Human Microbiome Journal · doi:10.1016/j.humic.2016.10.001 · Cited by 11
Delgado-Gardea, M. C. E., Tamez‐Guerra, P., Gomez‐Flores, R., Garfio-Aguirre, M., Rocha-Gutiérrez, B. A., Romo-Sáenz, C. I., de la Serna, F. J. Z.-D., de la Vega, G. E., Sánchez‐Ramírez, B., Horta, C. G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43489-9 · Cited by 11
Elwood, C. N., Albert, A., McClymont, E., Wagner, E. C., Mahal, D., Devakandan, K., Quigley, B. L., Pakzad, Z., Yudin, M. H., Je, H., et al. (2019) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15930 · Cited by 10
Lactic Acid Bacteria as Probiotics: Current Status and Future Prospects
Gill, P. K. (2023) · Asian Journal of Microbiology and Biotechnology · doi:10.56557/ajmab/2023/v8i28424 · Cited by 9
Schaefer, A., Yang, B., Schroeder, H. A., Harit, D., Humphry, M. S., Ravel, J., & Lai, S. K. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.031 · Cited by 9
Semen: A modulator of female genital tract inflammation and a vector for HIV‐1 transmission
Jewanraj, J., Ngcapu, S., & Liebenberg, L. J. P. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13478 · Cited by 8
Impact of bacterial vaginosis on sexually transmitted viral infections: a bacterial point of view
Segui‐Perez, C., van Smoorenburg, M. Y., Maranus, A. E., Geijtenbeek, T. B. H., & Strijbis, K. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf039 · Cited by 11
Aldunate, M., Tyssen, D. P., Johnson, A., Latham, C. F., Ellenberg, P. C., Cowieson, N. P., Hayward, J. A., Ramsland, P. A., Hearps, A. C., & Tachedjian, G. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013594 · Cited by 9
Podoprigora, I. V., Alena, V., Arsène, M. M. J., Sergueïevna, D. M., Alla, P. P., Кафарская, Л. И., & Boris, E. (2024) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2024.116419 · Cited by 8
Vaginal microbiota associated with oncogenic HPV in a cohort of HPV-vaccinated women living with HIV
McClymont, E., Albert, A., Wang, C., Santos, S. J. D., Coutlée, F., Lee, M. H., Walmsley, S. L., Lipsky, N., Loutfy, M. R., Trottier, S., et al. (2022) · International Journal of STD & AIDS · doi:10.1177/09564624221109686 · Cited by 8
The role of pharmacomicrobiomics in HIV prevention, treatment, and women’s health
Swanson, E. C., Basting, C. M., & Klatt, N. R. (2024) · Microbiome · doi:10.1186/s40168-024-01953-3 · Cited by 7
HIV Inhibition by Lactobacilli: Easier in a Test Tube Than in Real Life
Witkin, S. S., & Linhares, I. M. (2015) · mBio · doi:10.1128/mbio.01485-15 · Cited by 7
O’Hanlon, D. E., Brown, S. E., He, X., Stennett, C. A., Robbins, S., Johnston, E. D., Wnorowski, A. M., Mark, K., Ravel, J., Cone, R. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250153 · Cited by 7
Delgado-Diaz, D. J., Jesaveluk, B., Hayward, J. A., Tyssen, D. P., Alisoltani, A., Potgieter, M. G., Bell, L., Ross, E. J., Iranzadeh, A., Allali, I., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1352040/v1 · Cited by 7
Mucosal Microbes Mitigate Maladies
Vujkovic-Cvijin, I., & Deeks, S. G. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.019 · Cited by 6
Drozhdina, M. B. (2020) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma202019061926 · Cited by 5
Finzer, P., Küppers, V., & Griesser, H. (2023) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-2044-0162 · Cited by 5
Bommana, S., Hu, Y., Kama, M., Wang, R., Kodimerla, R., Jijakli, K., Read, T. D., & Dean, D. (2023) · mBio · doi:10.1128/mbio.03063-23 · Cited by 5
The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing
Todorov, S. D., Tagg, J. R., Algburi, A., Tiwari, S. K., Popov, I. V., Weeks, R. M., Mitrokhin, O. V., Kudryashov, I. A., Александрович, К. Д., & Chikindas, M. L. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10419-9 · Cited by 5
Mhlekude, B., Lenman, A., Sidoyi, P., Joseph, J. T., Kruppa, J., Businge, C. B., Mdaka, M. L., Konietschke, F., Pich, A., Gerold, G., et al. (2021) · AIDS · doi:10.1097/qad.0000000000003003 · Cited by 5
Animal Models Used to Study Superantigen-Mediated Diseases
Brosnahan, A. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3344-0_1 · Cited by 5
An update on Gardneralla vaginalis associated bacterial vaginosis in Malaysia
Younis, N. K., Gopinath, R., Jegasothy, R., Nordin, S. A., van Belkum, A., Joseph, N. M. S., & Neela, V. K. (2017) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2017.08.011 · Cited by 4
Compartmentalized Neuronal Culture for Viral Transport Research
Wang, Y., Wang, S., Wu, H., Liu, X., Ma, J., Khan, M. A., Riaz, A., Wang, L., Qiu, H., & Sun, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01470 · Cited by 4
del Zulia, U., & Núñez-Troconis, J. (2022) · Revista de Obstetricia y Ginecología de Venezuela · doi:10.51288/00820113 · Cited by 4
Atypical Viral Infections in Gastroenterology
Crnčević, N., Rifatbegović, Z., Hukić, M., Deumić, S., Pramenković, E., Selimagić, A., Gavrankapetanović, I., & Avdić, M. (2022) · Diseases · doi:10.3390/diseases10040087 · Cited by 4
Svanberg, C., Ellegård, R., Crisci, E., Khalid, M., Wodlin, N. B., Svenvik, M., Nyström, S. N., Birse, K., Burgener, A., Shankar, E. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625649 · Cited by 5
Onywera, H., Mbulawa, Z. Z. A., Brink, A. J., Williamson, A., & Mwapagha, L. M. (2024) · Venereology · doi:10.3390/venereology3040017 · Cited by 3
Kushiro, K., Hammers, S., Zhu, Y., Flowers, H. B., Dawson, L. N., Panjwani, A., Schaefer, A., Quan, D., Gibb, K., McSweeney, M. D., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113662 · Cited by 3
Real-time observation of bacterial gene expression noise
Anufrieva, O., Sala, A., Yli-Harja, O. P., & Kandhavelu, M. (2016) · Nano Communication Networks · doi:10.1016/j.nancom.2016.03.001 · Cited by 3
Violation of the vaginal microbiome and the risk of HIV infection in women
Khryanin, А. А., Knorring, G. Y., & Bocharova, V. K. (2023) · HIV Infection and Immunosuppressive Disorders · doi:10.22328/2077-9828-2023-15-1-23-31 · Cited by 3
Interactions between the epithelial barrier and the microbiota in the reproductive tract
Takada, K., Komine‐Aizawa, S., Tsuji, N. M., & Hayakawa, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818508-7.00002-6 · Cited by 3
Early prediction of preeclampsia using the first trimester vaginal microbiomePreprint
Kindschuh, W. F., Austin, G. I., Meydan, Y., Park, H., Urban, J. A., Watters, E., Pollak, S. V., Saade, G. R., Chung, J. M., Mercer, B. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.01.626267 · Cited by 3
Female Reproductive Tract Organ-on-Chips: Modeling Barrier Function and Drug Transport
Zhou, S., Xu, Z., & Shen, J. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030280 · Cited by 2
The cervicovaginal microbiome: an emerging determinant of HPV infection and disease
Spurgeon, M. E. (2026) · Journal of Virology · doi:10.1128/jvi.01706-25 · Cited by 2
Tasew, G., Gadisa, E., Abera, A., Zewude, A., Chanyalew, M., Aseffa, A., Abebe, M., Ritter, U., van Zandbergen, G., Laskay, T., et al. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1441-5 · Cited by 2
Whitlow, A., Herndon, M. K., Bova, J. E., & Campbell, R. B. P. (2019) · Current Clinical Microbiology Reports · doi:10.1007/s40588-019-00115-6 · Cited by 2
Tandon, D., Patil, A. D., & Goriwale, M. (2022) · medRxiv · doi:10.1101/2022.05.17.22275192 · Cited by 2
ZMapp reduces diffusion of Ebola viral particles in fresh human cervicovaginal mucus
Schaefer, A., Yang, B., Schroeder, H. A., Harit, D., Humphry, M. S., Zeitlin, L., Whaley, K. J., Ravel, J., Fischer, W. A., & Lai, S. K. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2352520 · Cited by 1
Paul, D., Choudhury, S., & Bose, S. K. (2018) · Springer eBooks · doi:10.1007/978-981-13-2925-8_6 · Cited by 1
Rennin and lecithin to treat vaginosis in a lesbian and bisex woman
Martini, L. (2022) · Our Dermatology Online · doi:10.7241/ourd.2022e.15 · Cited by 1
High-resolution functional description of vaginal microbiomes in health and diseasePreprint
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M. D., Forney, L. J., & Ravel, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.24.533147 · Cited by 1
Collins, S. L. (2017) · Scholarship@Western (Western University)
[Lactic acid inhibits the formation of semen-derived amyloid fibrils].
Li, J., Song, Y., Xun, T., Tan, S., & Liu, S. (2017) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2017.07.09
Resistance to human immunodeficiency virus infection: a rare but neglected state
Tamalet, C., Devaux, C. A., Dubourg, G., & Colson, P. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14452
Understanding mucus selective permeability across length scales
Samad, T. S. (2019) · DSpace@MIT (Massachusetts Institute of Technology)
Chen, Q., Jhong, J.-H., Li, S., Huang, C., & Lee, T.-Y. (2021) · Applied Microbiology open access
Larsen, B. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736405094.793578731
Larsen, B. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736814216.793576871
Svanberg, C. (2023) · Linköping University medical dissertations · doi:10.3384/9789180751230
Bommana, S., Hu, Y., Kama, M., Wang, R., Kodimerla, R., Jijakli, K., Read, T. D., & Dean, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.546186
Podoprigora, I. V., Alena, V., Manga, J. A. M., Sergueïevna, D. M., Pikina, A. P., Кафарская, Л. И., & Efimov, B. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4177720/v1
Additional file 18 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254241
Additional file 7 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254310
Additional file 15 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254223
Additional file 13 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254205
Additional file 14 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254214
Additional file 1 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254256
Additional file 20 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254265
Additional file 17 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254238
Additional file 10 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254178
Additional file 19 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254247
Additional file 8 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254313
Additional file 3 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254295
Transforming Infection Treatment with Microbiome-Based Therapeutics
Haider, A., Ali, A., Israr, M., Mariam, F., Rasheed, M. M., Taqveem, A., Waqas, U., Xu, D., Liu, Y., & Duan, T. (2024) · Springer eBooks · doi:10.1007/978-981-97-3790-1_16
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643538
Additional file 9 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254319
Additional file 2 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254289
Additional file 6 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254307
Additional file 12 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254196
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643529
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643526
Additional file 5 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254304
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643547
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643535
Delgado-Diaz, D. J., Jesaveluk, B., Hayward, J. A., Tyssen, D. P., Alisoltani, A., Potgieter, M. G., Bell, L., Ross, E. J., Iranzadeh, A., Allali, I., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20762886
Additional file 11 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254187
Additional file 4 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254298
Additional file 22 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254286
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643553
Additional file 16 of Novel high-resolution targeted sequencing of the cervicovaginal microbiome
Andralojc, K. M., Molina, M. A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M. A., Dutilh, B. E., Ederveen, T. H. A., Elmelik, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17254235
Holm, J. B., France, M., Gajer, P., Ma, B., Brotman, R. M., Shardell, M., Forney, L. J., & Ravel, J. (2024) · Figshare · doi:10.6084/m9.figshare.26643544
Metadata
- Authors
- Nunn, K. L., Wang, Y.-Y., Harit, D., Humphrys, M. S., Ma, B., Cone, R., Ravel, J., & Lai, S. K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Corresponding author
- Lai, Samuel K.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2015-10-30
- Volume
- 6
- Issue
- 5
- Pages
- e01084-15
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC4611035
- OpenAlex
- W2172682788
- Cited by
- 194
- References
- 49
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 13 · 2023: 17 · 2022: 24 · 2021: 34 · 2020: 18 · 2019: 17 · 2018: 22 · 2017: 16 · 2016: 12 · 2015: 3
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (1f32ai102535-01)
- University of North Carolina at Chapel Hill
- National Institute of General Medical Sciences (R25GM089569)
- National Institute of Allergy and Infectious Diseases (U19AI084044, R21AI093242, F32 AI102535, U19AI096398, P30 AI50410, 1F32AI102535, P30AI050410)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- HIV-1, cervicovaginal mucus, vaginal microbiota, Lactobacillus crispatus, Lactobacillus iners, Gardnerella vaginalis, bacterial vaginosis, mucus barrier, virus trapping, D-lactate, HIV acquisition, sexually transmitted infections, particle tracking
- MeSH terms
- Adult, Cervix Uteri, Female, Gardnerella vaginalis, Humans, Hydrogen-Ion Concentration, Lactobacillus, Mucus, Vagina, HIV-1, Lactic Acid, Young Adult
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