Bacterial Longevity Requires Protein Synthesis and a Stringent Response
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Abstract
We are surrounded by bacteria, but they do not completely dominate our planet despite the ability of many to grow extremely rapidly in the laboratory. This has been interpreted to mean that bacteria in nature are often in a dormant state. We investigated life in growth arrest of Rhodopseudomonas palustris , a proteobacterium that stays alive for months when it is not growing. We found that cells were metabolically active, and they continued to synthesize proteins and mounted a stringent response, both of which were required for their longevity. Our results suggest that long-lived bacteria are not necessarily inactive but have an active metabolism that is well adjusted to life without growth.
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- Authors
- Yin, L., Ma, H., Nakayasu, E. S., Payne, S. H., Morris, D. R., & Harwood, C. S.
- Affiliations
- University of Washington (US)
- Pacific Northwest National Laboratory (US)
- Brigham Young University (US)
- Corresponding author
- Harwood, Caroline S.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2019-10-29
- Volume
- 10
- Issue
- 5
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC6794480
- OpenAlex
- W2981127978
- Cited by
- 31
- References
- 4
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 6
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- U.S. Department of Energy (DE-AC05-76RLO01830)
- DOD | United States Army | RDECOM | Army Research Office (W911NF-15-1-0150)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- bacterial longevity, stringent response, protein synthesis, Rhodopseudomonas palustris, growth arrest, bacterial dormancy, metabolic activity, Proteobacteria
- MeSH terms
- Anti-Bacterial Agents, Bacterial Proteins, Models, Biological, Rhodopseudomonas, Proteome
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