Persister cells

Bacterial Biofilms: A Common Cause of Persistent Infections

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Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

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Antibacterial resistance worldwide: causes, challenges and responses

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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics

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Bacterial Persistence as a Phenotypic Switch

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Stochasticity in gene expression: from theories to phenotypes

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Chemotaxis in Escherichia coli analysed by Three-dimensional Tracking

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Persister cells, dormancy and infectious disease

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TOR, a central controller of cell growth.

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Riddle of Biofilm Resistance

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Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis

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The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

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Genetic adaptation by <i>Pseudomonas aeruginosa</i> to the airways of cystic fibrosis patients

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TREATMENT OF STAPHYLOCOCCAL INFECTIONS WITH PENICILLIN BY INTERMITTENT STERILISATION

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Persister cells and tolerance to antimicrobials

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Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin

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Bacterially Speaking

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Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials

Spoering, A. L., & Lewis, K. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6746-6751.2001 · Cited by 907 · see citing works

Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes

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Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli

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Comparative Gene Expression Profiles Following UV Exposure in Wild-Type and SOS-Deficient <i>Escherichia coli</i>

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Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

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Bistability in bacteria

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Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.

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The Challenge of Treating Biofilm-associated Bacterial Infections

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Noise in Gene Expression Determines Cell Fate in <i>Bacillus subtilis</i>

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hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis

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Persisters: a distinct physiological state of E. coli

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Antibiotics

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Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system

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Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

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Programmed Death in Bacteria

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Toxins-Antitoxins: Plasmid Maintenance, Programmed Cell Death, and Cell Cycle Arrest

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Cannibalism by sporulating bacteria.

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Identification of additional genes belonging to the LexA regulon in Escherichia coli

de Henestrosa, A. R. F., Ogi, T., Aoyagi, S., Chafin, D. R., Hayes, J. J., Ohmori, H., & Woodgate, R. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01826.x · Cited by 566 · see citing works

SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli

Dörr, T., Lewis, K., & Vulić, M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000760 · Cited by 530 · see citing works

Non-genetic individuality: chance in the single cell

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Mechanisms of Action of Antimicrobials: Focus on Fluoroquinolones

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Plant defense peptides

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Microbial Cell Individuality and the Underlying Sources of Heterogeneity

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<i>Candida albicans</i> Biofilms Produce Antifungal-Tolerant Persister Cells

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Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

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LANTIBIOTICS: Biosynthesis and Biological Activities of Uniquely Modified Peptides from Gram-Positive Bacteria

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A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

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From molecular noise to behavioural variability in a single bacterium

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Human Leukocytes Adhere to, Penetrate, and Respond to Staphylococcus aureus Biofilms

Leid, J. G., Shirtliff, M. E., Costerton, J. W., & Stoodley, A. P. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.6339-6345.2002 · Cited by 406 · see citing works

Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis

Korch, S. B., Henderson, T. A., & Hill, T. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03779.x · Cited by 400 · see citing works

The biological role of death and lysis in biofilm development

Bayles, K. W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1743 · Cited by 376 · see citing works

Compromised Host Defense on Pseudomonas aeruginosa Biofilms: Characterization of Neutrophil and Biofilm Interactions

Jesaitis, A. J., Franklin, M. J., Berglund, D. L., Sasaki, M., Lord, C. I., Bleazard, J. B., Duffy, J. E., Beyenal, H., & Lewandowski, Z. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4329 · Cited by 368 · see citing works

Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins

Pedersen, K. B., Christensen, S. K., & Gerdes, K. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03027.x · Cited by 360 · see citing works

Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009) · Science · doi:10.1126/science.1163806 · Cited by 351 · see citing works

Bistability and biofilm formation in Bacillus subtilis

Chai, Y., Chu, F., Kolter, R., & Losick, R. M. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.06040.x · Cited by 338 · see citing works

RelE toxins from Bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA

Christensen, S. K., & Gerdes, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03512.x · Cited by 338 · see citing works

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

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Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides.

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Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon.

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The Small RNA IstR Inhibits Synthesis of an SOS-Induced Toxic Peptide

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An antisense RNA controls synthesis of an SOS‐induced toxin evolved from an antitoxin

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Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of <i>Candida albicans</i>

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Increased Persistence in Escherichia coli Caused by Controlled Expression of Toxins or Other Unrelated Proteins

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Ectopic Overexpression of Wild-Type and Mutant hipA Genes in Escherichia coli : Effects on Macromolecular Synthesis and Persister Formation

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PhoU Is a Persistence Switch Involved in Persister Formation and Tolerance to Multiple Antibiotics and Stresses in Escherichia coli

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Phenotypic Tolerance: Antibiotic Enrichment of Noninherited Resistance in Bacterial Populations

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GlpD and PlsB Participate in Persister Cell Formation in Escherichia coli

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Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa

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Kinase Activity of Overexpressed HipA Is Required for Growth Arrest and Multidrug Tolerance in Escherichia coli

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A small SOS‐induced toxin is targeted against the inner membrane in Escherichia coli

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Induction of the SOS response by new 4-quinolones

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The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm

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Multiple hok genes on the chromosome of Escherichia coli

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Biofilms, Infection, and Antimicrobial Therapy

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Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis

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Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis

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The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

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Helicobacter pylori–Related Disease

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Novel persistence genes in Pseudomonas aeruginosa identified by high-throughput screening

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Joint Tolerance to β-Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA

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Central Nervous System Infections: Meningitis and Brain Abscess

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Persister cells mediate tolerance to metal oxyanions in Escherichia coli

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Conditional impairment of cell division and altered lethality in hipA mutants of Escherichia coli K-12

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Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some <i>Candida</i> Species

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Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module

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Hydrophobic peptides: novel regulators within bacterial membrane

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The dinB Operon and Spontaneous Mutation in Escherichia coli

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Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phaseEscherichia coli

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An SOS-Regulated Type 2 Toxin-Antitoxin System

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A subpopulation ofCandida albicansandCandida tropicalisbiofilm cells are highly tolerant to chelating agents

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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

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Implant infections: adhesion, biofilm formation and immune evasion

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Patterns and Processes of Microbial Community Assembly

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Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

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Platforms for antibiotic discovery

Lewis, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3975 · Cited by 1,449 · see citing works

Antimicrobial Peptides

Bahar, A. A., & Ren, D. (2013) · Pharmaceuticals · doi:10.3390/ph6121543 · Cited by 1,387 · see citing works

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

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Persistent bacterial infections and persister cells

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Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention

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