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Cited by 24Viral-associated cancers and disordersHerpesvirus Infections and Treatmentsinterferon and immune responses

25-Hydroxycholesterol Inhibits Kaposi’s Sarcoma Herpesvirus and Epstein-Barr Virus Infections and Activates Inflammatory Cytokine Responses

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Serquiña, Anna K. P., Tagawa, Takanobu, Oh, Daniel, Mahesh, Guruswamy, Ziegelbauer, Joseph M.·2021·mBio
DOI 10.1128/mbio.02907-21PMC PMC8593836
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Abstract

A cholesterol derivative, 25-hydroxycholesterol (25HC), has been demonstrated to inhibit infections from widely different bacteria and viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, its mechanism of activity is still not fully understood.

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  • 25-hydroxycholesterol blocks de novo EBV infection of B cells.

    “and, as recently described, including also de novo EBV infection of B cells43.”

    From Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response (2022) · cites this paper as [43]

    The Results section ('25HC inhibited EBV infection'; page not provided) shows that 25HC impaired outcomes of de novo EBV infection in B-cell-enriched samples, particularly proliferation and transformation. It does not show that 25HC blocks infection itself: GFP-positive infected cells remained after treatment. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • 25-HC is effective against de novo EBV infection by suppressing key viral genes and interfering with viral induced proliferation.

    “also against de novo EBV infection by suppressing key viral genes and interfering with viral induced proliferation43”

    From Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response (2022) · cites this paper as [43]

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Cited by

Sorted by citations

Authors
Serquiña, A. K. P., Tagawa, T., Oh, D., Mahesh, G., & Ziegelbauer, J. M.
Affiliations
National Institutes of Health (US)
Corresponding author
Ziegelbauer, Joseph M.
ORCID
Venue
mBio
Publisher
American Society for Microbiology
Published
2021-12-21
Volume
12
Issue
6
Pages
e0290721-e0290721
ISSN
2150-7511 (ISSN-L)
DOI
10.1128/mbio.02907-21
PMC
PMC8593836
OpenAlex
W3211889235
Cited by
24
References
1
Citations by year
2026: 5 · 2025: 6 · 2024: 1 · 2023: 8 · 2022: 4
FWCI
1.27
Type
journal article
Language
en
Open access
Licence
Locations
  • mBio (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
HHS | NIH | National Cancer Institute (1ZIABC011176)
Topics
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
25-hydroxycholesterol, Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, antiviral activity, cholesterol derivatives, viral gene expression, host-virus interaction, inflammatory cytokines, host response to viral infection
MeSH terms
B-Lymphocytes, Cells, Cultured, Herpesvirus 4, Human, Humans, Hydroxycholesterols, Inflammation, Virus Replication, Gene Expression Regulation, Viral, Cytokines, Sequence Analysis, RNA, Virus Latency, Herpesvirus 8, Human, Epstein-Barr Virus Infections, Endothelial Cells

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