The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1
Open accessAbstract
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of the Orai1 gene. The results of immunohistochemical analysis showed that ORAI1 is expressed in lymphocytes, skin, and muscle of wild-type mice and is not expressed in Orai1(-/-) mice. Orai1(-/-) mice with the inbred C57BL/6 background showed perinatal lethality, which was overcome by crossing them to outbred ICR mice. Orai1(-/-) mice were small in size, with eyelid irritation and sporadic hair loss resembling the cyclical alopecia observed in mice with keratinocyte-specific deletion of the Cnb1 gene. T and B cells developed normally in Orai1(-/-) mice, but B cells showed a substantial decrease in Ca(2+) influx and cell proliferation in response to B-cell receptor stimulation. Naïve and differentiated Orai1(-/-) T cells showed substantial reductions in store-operated Ca(2+) entry, CRAC currents, and cytokine production. These features are consistent with the severe combined immunodeficiency and mild extraimmunological symptoms observed in a patient with a missense mutation in human ORAI1 and distinguish the ORAI1-null mice described here from a previously reported Orai1 gene-trap mutant mouse which may be a hypomorph rather than a true null.
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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
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Self-citationSTIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
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STIM1, an essential and conserved component of store-operated Ca2 + channel function
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Depletion of intracellular calcium stores activates a calcium current in mast cells
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Orai1 is an essential pore subunit of the CRAC channel
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Self-citationCRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
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Calcium signalling in lymphocyte activation and disease
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Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,239
Self-citationMolecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
Self-citationThe functional network of ion channels in T lymphocytes
Cahalan, M. D., & Chandy, K. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00816.x · Cited by 599
Ion channels and transporters in lymphocyte function and immunity
Feske, S., Skolnik, E. Y., & Prakriya, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3233 · Cited by 441
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Metadata
- Authors
- Gwack, Y., Srikanth, S., Oh-hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K., & Rao, A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-09-01
- Volume
- 28
- Issue
- 17
- Pages
- 5209-5222
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2112645751
- Cited by
- 288
- References
- 57
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1. https://app.cochat.ai/papers/10.1128/mcb.00360-08
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- Gwack, Y., Srikanth, S., Oh-hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K., & Rao, A. (2008). Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00360-08
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