The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.
Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
Open accessAbstract
Ca 2+entry into cells of the peripheral immune system occurs through highly Ca 2+-selective channels known as CRAC (calcium release-activated calcium) channels. CRAC channels are a very well-characterized example of store-operated Ca 2+channels, so designated because they open when the endoplasmic reticulum (ER) Ca 2+store becomes depleted. Physiologically, Ca 2+is released from the ER lumen into the cytoplasm when activated receptors couple to phospholipase C and trigger production of the second messenger inositol 1,4,5-trisphosphate (IP 3). IP 3 binds to IP 3 receptors in the ER membrane and activates Ca 2+release. The proteins STIM and ORAI were discovered through limited and genome-wide RNAi screens, respectively, performed in Drosophila cells and focused on identifying modulators of store-operated Ca 2+entry. STIM1 and STIM2 sense the depletion of ER Ca 2+stores, whereas ORAI1 is a pore subunit of the CRAC channel. In this review, we discuss selected aspects of Ca 2+signaling in cells of the immune system, focusing on the roles of STIM and ORAI proteins in store-operated Ca 2+entry.
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Self-citationSTIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
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Cited by
Seo, H., Chen, J., González-Avalos, E., Samaniego-Castruita, D., Das, A., Wang, Y. H., López-Moyado, I. F., Georges, R. O., Zhang, W., Onodera, A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905675116 · Cited by 808
Self-citationIon channels and transporters in lymphocyte function and immunity
Feske, S., Skolnik, E. Y., & Prakriya, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3233 · Cited by 441
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
Bertin, S., Aoki-Nonaka, Y., de Jong, P. R., Nohara, L. L., Xu, H., Stanwood, S. R., Srikanth, S., Lee, J., To, K., Abramson, L., et al. (2014) · Nature Immunology · doi:10.1038/ni.3009 · Cited by 260
Ahuja, M., Schwartz, D. M., Tandon, M., Son, A., Zeng, M., Swaim, W., Eckhaus, M., Hoffman, V., Cui, Y., Xiao, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.007 · Cited by 195
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Metadata
- Authors
- Hogan, P. G., Lewis, R. S., & Rao, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 491-533
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2132781656
- Cited by
- 760
- References
- 217
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Hogan, P. G., Lewis, R. S., & Rao, A. (2010). Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.021908.132550
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