Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
Lau, Lena, Porciuncula, Angelo, Yu, Alex, Iwakura, Yoichiro, David, Gregory·2019·Molecular and Cellular Biology
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- CDK4/6 inhibition induces a DNA damage-independent senescence-associated secretory phenotype driven by delayed activation of NF-κBJoanna Lan-Hing Yeung, Justin Rendleman, Lauren Anderson Westcott, Arnold Ou, Matthew Pressler, Nicole Pagane, Irene Duba, Ria Hosuru, Bat‐Ider Tumenbayar, Viviana I. Risca · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Pan-cancer landscape of cellular senescence heterogeneity reveals associations with prognosis and therapy responseLinyan Chen, Tongshu Yang, Zhiyuan Zhang, Yuqi Yang, Sidian Long, Manhua Wang, Hao Zeng · 2025 · Scientific Reports
- Advanced drug delivery platforms targeting cellular senescence: A promising strategy for cancer therapyXue Zhang, Lingxiao Yang, Xiaopeng He, Min Zhao, Zaixiang Fang, Gang Xu, Zhenyu Duan, Kui Luo · 2026 · Acta Pharmaceutica Sinica B
- Plasticité cellulaire et initiation tumorale dans le modèle du cancer du seinHadrien De Blander · 2020 · theses.fr (ABES)
- Epigenetic characterization of cellular pliancy in breast cancerRahma Benhassoun · 2024 · theses.fr (ABES)
- Transcriptional regulation in cardiovascular agingYiguang Fan, Chao Song, Fangnan Feng, Qing Xun, Yuhao Lu, Chunquan Li · 2026 · Frontiers in Cardiovascular Medicine
- CDK4/6-targeted therapy for gastrointestinal cancers: from resistance mechanisms to immuno-combination strategies guided by biomarkersJunhao Cui, Yanchuan Zhang, Yongfang Wu, Guangjie Zhang, Jie Lan, Yingshuang Wang · 2026 · Frontiers in Immunology
- Differential Enhancer Activity and FOXF1 Levels Contribute to Higher Inflammatory Gene Expression of Fetal/Neonatal Versus Adult Fibroblasts in IR-induced SenescenceReem Hamed, Régis Courbeyrette, Alexander G. Foote, Susan L. Thibeault, Nicolas O. Fortunel, Laure Crabbé, Carl Mann · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- A senescence-associated gene signature predicts radiotherapy prognosis in non-small cell lung cancer and identifies CSF1 as a target to potentiate radioimmunotherapyShaochuan Liu, Y Zhang, Li Li, Huanhuan Wang, Hao Yuan, D C Zhang, Donghe Zhao, Yong Guan, Zhiyong Yuan · 2026 · Biology Direct
- IL-1-mediated cancer-adapted hematopoiesis in aging and clonal hematopoiesisFrancisco Caiado, Nagihan G. Gonullu, Markus Gabriel Manz · 2026 · Seminars in Immunology
- The emerging role of aging in tumorigenesisXiaofen Wu, Hui Wang, Yuguo Liu, Ping Hu · 2026 · Cell investigation.
- IL-1 signaling in cancer-associated fibroblasts: shaping fibroblast heterogeneity, tumor immunity, and therapeutic resistanceMonica Gabola, Mohaned Benzarti, Elisabeth Letellier · 2026 · Seminars in Immunology
- Cellular senescence in multiple sclerosis: hallmarks, immunosenescence, and therapeutic implicationsAla Yousef, John M. Seubert, Christopher Power, Nabeela Nathoo · 2026 · Frontiers in Immunology
- IL-1β/IL-6 inflammatory crosstalk drives DNA methylation and histone remodeling associated with cytokine induced senescence in luminal breast cancerSatyajit Dey Pereira, Kanaka Sai Ram Padam, Padival Shruptha, Aditi Atreya, Manjunath Bandu Joshi, Kapaettu Satyamoorthy · 2026 · Inflammation Research