Iwakura, Yoichiro

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature

Gut microbiota and healthTelomeres, Telomerase, and Senescence

Cited by 2,219

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 1,554

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 1,536

Functional Specialization of Interleukin-17 Family Members

Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 1,289

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses

Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,004

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 842

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 756

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., & Seishima, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 748

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., & Iwakura, Y. (1998) · The Journal of Experimental Medicine

Inflammasome and immune disordersThermal Regulation in Medicine

Cited by 611

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction

Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., & Hirano, T. (2008) · Immunity

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 564

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation

Park, S.-J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S.-I., Kamimura, D., Ueda, N., Iwakura, Y., Ishihara, K., et al. (2004) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmunotherapy and Immune Responses

Cited by 519

IL-17-producing γδ T cells enhance bone regeneration

Ono, T., Okamoto, K., Nakashima, T., Nitta, T., Hori, S., Iwakura, Y., & Takayanagi, H. (2016) · Nature Communications

Bone Metabolism and DiseasesT-cell and B-cell Immunology

Cited by 371

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity

Chemokine receptors and signalingRheumatoid Arthritis Research and Therapies

Cited by 342

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

Baldeviano, G. C., Barin, J. G., Talor, M. V., Srinivasan, S., Bedja, D., Zheng, D., Gabrielson, K., Iwakura, Y., Rose, N. R., & Cihakova, D. (2010) · Circulation Research

Viral Infections and Immunology ResearchCardiac Fibrosis and Remodeling

Cited by 334

Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier

Arima, Y., Harada, M., Kamimura, D., Park, J.-H., Kawano, F., Yull, F. E., Kawamoto, T., Iwakura, Y., Betz, U. A. K., Márquez, G., et al. (2012) · Cell

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

Tang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe

Gut microbiota and healthInflammatory Bowel Disease

Cited by 285

Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors

Krelin, Y., Voronov, E., Dotan, S., Elkabets, M., Reich, E., Fogel, M., Huszar, M., Iwakura, Y., Segal, S., Dinarello, C. A., et al. (2007) · Cancer Research

Immune cells in cancerImmunotoxicology and immune responses

Cited by 285

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

Nakae, S., Iwakura, Y., Suto, H., & Galli, S. J. (2007) · Journal of Leukocyte Biology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 282

Growth retardation and early death of β‐1, 4‐galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells

Asano, M., Furukawa, K., Kido, M., Matsumoto, S., Umesaki, Y., Kochibe, N., & Iwakura, Y. (1997) · The EMBO Journal

Glycosylation and Glycoproteins ResearchDigestive system and related health

Cited by 270

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

Kubota, N., Kubota, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Mineyama, T., Ogata, H., Tokuyama, K., Ohsugi, M., et al. (2008) · Cell Metabolism

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 244

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

Eigenbrod, T., Park, J.-H., Harder, J., Iwakura, Y., & Núñez, G. (2008) · The Journal of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 228

IL-1 plays an important role in the bone metabolism under physiological conditions

Lee, Y.-M., Fujikado, N., Manaka, H., Yasuda, H., & Iwakura, Y. (2010) · International Immunology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 226

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

Drummond, R. A., Saijo, S., Iwakura, Y., & Brown, G. D. (2011) · European Journal of Immunology

Immune Response and InflammationAntifungal resistance and susceptibility

Cited by 221

Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy

Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G. C., Kass, D. A., Bedja, D., Zhang, H., Sheikh, A., Margolick, J. B., et al. (2014) · Journal of Experimental Medicine

Cardiac Fibrosis and RemodelingViral Infections and Immunology Research

Cited by 181