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Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
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LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors.
“LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors [2, 7, 10, 24, 25, 36, 51, 59, 62, 75, 77, 96].”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [62]
The section on LRRK2 WD40 neurotoxicity reports an exoendocytotic assay in which WD40 overexpression reduced synaptotagmin uptake, supporting a role in synaptic vesicle cycling. The Discussion also links LRRK2 to vesicle trafficking. The passages found do not support the additional claims about activation of autophagy or axonal transport of growth factor receptors. Page numbers were not available in our copy. (LLM, conf=0.86)
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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Verma, M., Lizama, B. N., & Chu, C. T. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-021-00278-7 · Cited by 451
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau
McInnes, J., Wierda, K., Snellinx, A., Bounti, L., Wang, Y.-C., Stancu, I.-C., Apóstolo, N., Gevaert, K., Dewachter, I., Spires-Jones, T. L., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.022 · Cited by 242
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Singh, V., Menard, M. A., Serrano, G. E., Beach, T. G., Zhao, H. T., Riley-DiPaolo, A., Subrahmanian, N., LaVoie, M. J., & Volpicelli-Daley, L. A. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01704-9 · Cited by 9
Metadata
- Authors
- Piccoli, G., Onofri, F., Cirnaru, M. D., Kaiser, C. J. O., Jagtap, P., Kastenmüller, A., Pischedda, F., Marte, A., von Zweydorf, F., Vogt, A., Giesert, F., Pan, L., Antonucci, F., Kiel, C., Zhang, M., Weinkauf, S., Sattler, M., Sala, C., Matteoli, M., Ueffing, M., & Gloeckner, C. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2014-06-01
- Volume
- 34
- Issue
- 12
- Pages
- 2147-2161
- ISSN
- 1098-5549
- Cited by
- 113
- References
- 1
- Language
- en
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