Cited by 113

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Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

Piccoli, Giovanni, Onofri, Franco, Cirnaru, Maria Daniela, Kaiser, Christoph J. O., Jagtap, Pravinkumar, Kastenmüller, Andreas, Pischedda, Francesca, Marte, Antonella, von Zweydorf, Felix, Vogt, Andreas, Giesert, Florian, Pan, Lifeng, Antonucci, Flavia, Kiel, Christina, Zhang, Mingjie, Weinkauf, Sevil, Sattler, Michael, Sala, Carlo, Matteoli, Michela, Ueffing, Marius, Gloeckner, Christian Johannes·2014·Molecular and Cellular Biology

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Crossref · 10.1128/mcb.00914-13

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  • LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors.

    “LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors [2, 7, 10, 24, 25, 36, 51, 59, 62, 75, 77, 96].”

    From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [62]

    The section on LRRK2 WD40 neurotoxicity reports an exoendocytotic assay in which WD40 overexpression reduced synaptotagmin uptake, supporting a role in synaptic vesicle cycling. The Discussion also links LRRK2 to vesicle trafficking. The passages found do not support the additional claims about activation of autophagy or axonal transport of growth factor receptors. Page numbers were not available in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 63

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Metadata

Authors
Piccoli, G., Onofri, F., Cirnaru, M. D., Kaiser, C. J. O., Jagtap, P., Kastenmüller, A., Pischedda, F., Marte, A., von Zweydorf, F., Vogt, A., Giesert, F., Pan, L., Antonucci, F., Kiel, C., Zhang, M., Weinkauf, S., Sattler, M., Sala, C., Matteoli, M., Ueffing, M., & Gloeckner, C. J.
Venue
Molecular and Cellular Biology
Published
2014-06-01
Volume
34
Issue
12
Pages
2147-2161
ISSN
1098-5549
Cited by
113
References
1
Language
en

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