The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice
Open accessAbstract
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3(-/-) mice and analyzed the neuronal phenotype. Reduced apoptosis in superior cervical ganglion (SCG) neurons cultured from PHD3(-/-) mice is associated with an increase in the number of cells in the SCG, as well as in the adrenal medulla and carotid body. Genetic analysis by intercrossing PHD3(-/-) mice with HIF-1a(+/-) and HIF-2a(+/-) mice demonstrated an interaction with HIF-2alpha but not HIF-1alpha, supporting the nonredundant involvement of a PHD3-HIF-2alpha pathway in the regulation of sympathoadrenal development. Despite the increased number of cells, the sympathoadrenal system appeared hypofunctional in PHD3(-/-) mice, with reduced target tissue innervation, adrenal medullary secretory capacity, sympathoadrenal responses, and systemic blood pressure. These observations suggest that the role of PHD3 in sympathoadrenal development extends beyond simple control of cell survival and organ mass, with functional PHD3 being required for proper anatomical and physiological integrity of the system. Perturbation of this interface between developmental and adaptive signaling by hypoxic, metabolic, or other stresses could have important effects on key sympathoadrenal functions, such as blood pressure regulation.
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Cites
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
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Self-citationNew stereological methods for counting neurons
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“Since homozygous inactivation of HIF-1 or HIF-2 results in embryonic lethality (20, 33 , 34, 42), we analyzed the effects of heterozygous inactivation by generating appropriate crosses with PHD3/ animals to allow for littermate comparisons.”
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Cited by
Prabhakar, N. R., & Semenza, G. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00030.2011 · Cited by 641
Hypoxia: an alarm signal during intestinal inflammation
Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461
Bardella, C., Pollard, P. J., & Tomlinson, I. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.07.003 · Cited by 395
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Fraisl, P., Aragonés, J., & Carmeliet, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2761 · Cited by 326
Self-citationVHL and HIF signalling in renal cell carcinogenesis
Baldewijns, M. M., van Vlodrop, I. J., Vermeulen, P. B., Soetekouw, P. M., van Engeland, M., & de Bruïne, A. P. (2010) · The Journal of Pathology · doi:10.1002/path.2689 · Cited by 316
Metadata
- Authors
- Bishop, T., Gallagher, D., Pascual, A., Lygate, C. A., de Bono, J. P., Nicholls, L. G., Ortega-Saenz, P., Oster, H., Wijeyekoon, B., Sutherland, A. I., Grosfeld, A., Aragones, J., Schneider, M., van Geyte, K., Teixeira, D., Diez-Juan, A., Lopez-Barneo, J., Channon, K. M., Maxwell, P. H., Pugh, C. W., Davies, A. M., Carmeliet, P., & Ratcliffe, P. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-05-01
- Volume
- 28
- Issue
- 10
- Pages
- 3386-3400
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2147891751
- Cited by
- 187
- References
- 13
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Bishop, T., Gallagher, D., Pascual, A., Lygate, C. A., de Bono, J. P., Nicholls, L. G., Ortega-Saenz, P., Oster, H., Wijeyekoon, B., Sutherland, A. I., Grosfeld, A., Aragones, J., Schneider, M., van Geyte, K., Teixeira, D., Diez-Juan, A., Lopez-Barneo, J., Channon, K. M., Maxwell, P. H., . . . Ratcliffe, P. J. (2008). Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.02041-07
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
