Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Global Prevalence of Diabetes

Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

Hypoxia — a key regulatory factor in tumour growth

Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1× · see citing works

Mechanisms of angiogenesis and arteriogenesis

Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,146 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 1× · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046 · see citing works

ARACHIDONIC ACID METABOLISM

Needleman, P., Truk, J., Jakschik, B. A., Morrison, A. R., & Lefkowith, J. B. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.000441 · Cited by 1,809 · see citing works

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520 · see citing works

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

Murphy, E., & Steenbergen, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00024.2007 · Cited by 1,472 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1× · see citing works

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225 · see citing works

Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature

Carey, H. V., Andrews, M. T., & Martin, S. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00008.2003 · Cited by 1,145 · see citing works

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891 · see citing works

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of <i>ob</i> / <i>ob</i> and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works

Untitled work

(2002) · PubMed · Cited by 840 · see citing works

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788 · see citing works

Cerebral preconditioning and ischaemic tolerance

Gidday, J. M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1927 · Cited by 751 · see citing works

Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

DeYoung, M. P., Horak, P., Sofer, A., Sgroi, D., & Ellisen, L. W. (2008) · Genes &amp; Development · doi:10.1101/gad.1617608 · Cited by 710 · see citing works

Vascular Endothelial Growth Factor-A Is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant during the Adaptive Response to Ischemic Injury

Nishijima, K., Ng, Y., Zhong, L., Bradley, J. M. B., Schubert, W., Jo, N., Akita, J., Samuelsson, S. J., Robinson, G. S., Adamis, A. P., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061237 · Cited by 705 · see citing works

HIF-1α expression regulates the bactericidal capacity of phagocytes

Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A. L., Theodorakis, E. A., Gallo, R. L., Hurtado‐Ziola, N., Nizet, V., & Johnson, R. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23865 · Cited by 702 · see citing works

Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N. A., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15337 · Cited by 679 · see citing works

Ecto-5′-Nucleotidase (CD73) Regulation by Hypoxia-Inducible Factor-1 Mediates Permeability Changes in Intestinal Epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660 · see citing works

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.010 · Cited by 607 · see citing works

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Günzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192342099 · Cited by 561 · see citing works

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

Grimm, C., Wenzel, A., Groszer, M., Mayser, H., Seeliger, M. W., Samardzija, M., Bauer, C., Gassmann, M., & Remé, C. E. (2002) · Nature Medicine · doi:10.1038/nm723 · Cited by 517 · see citing works

Ischemic preconditioning protects by activating prosurvival kinases at reperfusion

Hausenloy, D. J., Tsang, A., Mocanu, M. M., & Yellon, D. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2004 · Cited by 512 · see citing works

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., et al. (2002) · Nature Genetics · doi:10.1038/ng1019 · Cited by 510 · see citing works

Lipid accumulation in non-adipose tissue and lipotoxicity

van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500 · see citing works

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496 · see citing works

Cutting Edge: Essential Role of Hypoxia Inducible Factor-1α in Development of Lipopolysaccharide-Induced Sepsis

Peyssonnaux, C., Cejudo-Martin, P., Doedens, A., Zinkernagel, A. S., Johnson, R. S., & Nizet, V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7516 · Cited by 480 · see citing works

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Aragonés, J., Schneider, M. A., Geyte, K. V., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.62 · Cited by 472 · see citing works

Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13

Yun, Z., Maecker, H. L., Johnson, R. S., & Giaccia, A. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00131-4 · Cited by 460 · see citing works

The Reperfusion Injury Salvage Kinase Pathway: A Common Target for Both Ischemic Preconditioning and Postconditioning

Hausenloy, D. J., Tsang, A., & Yellon, D. M. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.03.001 · Cited by 449 · see citing works

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312254200 · Cited by 447 · see citing works

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Dahia, P. L. M., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010008 · Cited by 443 · see citing works

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

Eckle, T. D. L. G., Köhler, D., Lehmann, R., Kasmi, K. C. E., & Eltzschig, H. K. (2008) · Circulation · doi:10.1161/circulationaha.107.758516 · Cited by 410 · see citing works

Angiogenesis

Simons, M. (2005) · Circulation · doi:10.1161/01.cir.0000159345.00591.8f · Cited by 410 · see citing works

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works

Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

Takeda, K., Ho, V. C., Takeda, H., Duan, L.-J., Nagy, A., & Fong, G.-H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00425-06 · Cited by 401 · see citing works

Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states

Stenzel‐Poore, M. P., Stevens, S. L., Xiong, Z., Lessov, N. S., Harrington, C. A., Mori, M., Meller, R., Rosenzweig, H. L., Tobar, E., Shaw, T., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14412-1 · Cited by 394 · see citing works

Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200644200 · Cited by 391 · see citing works

The role of mitochondria in protection of the heart by preconditioning

Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390 · see citing works

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

Guo, Y., Jones, W. K., Xuan, Y., Tang, X., Bao, W., Wu, W., Han, H. L., Laubach, V. E., Ping, P., Yang, Z., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11507 · Cited by 386 · see citing works

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

McDonough, M. A., Li, V., Flashman, E., Chowdhury, R., Mohr, C., Liénard, B. M. R., Zondlo, J., Oldham, N. J., Clifton, I. J., Lewis, J. K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601283103 · Cited by 366 · see citing works

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca 2+ Overload During Simulated Ischemia and Reperfusion

Murata, M., Akao, M., O'Rourke, B. P., & Marbán, E. (2001) · Circulation Research · doi:10.1161/hh2201.100205 · Cited by 365 · see citing works

Normobaric Hypoxia Induces Tolerance to Focal Permanent Cerebral Ischemia in Association with an Increased Expression of Hypoxia-Inducible Factor-1 and its Target Genes, Erythropoietin and VEGF, in the Adult Mouse Brain

Bernaudin, M., Nedelec, A.-S., Divoux, D., MacKenzie, E. T., Petit, E., & Schumann‐Bard, P. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00003 · Cited by 352 · see citing works

Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia

Baranova, O., Miranda, L. F., Pichiule, P., Dragatsis, I., Johnson, R. S., & Chavez, J. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0449-07.2007 · Cited by 350 · see citing works

Insulin-Resistant Cardiomyopathy

Witteles, R. M., & Fowler, M. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.021 · Cited by 349 · see citing works

HIF‐dependent induction of adenosine A2B receptor in hypoxia

Kong, T., Westerman, K. A., Faigle, M., Eltzschig, H. K., & Colgan, S. P. (2006) · The FASEB Journal · doi:10.1096/fj.06-6419com · Cited by 338 · see citing works

The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressorPreprint

Schlisio, S., Kenchappa, R. S., Vredeveld, L. C. W., George, R. E., Stewart, R. A., Greulich, H. E., Shahriari, K. S., Nguyen, N. V., Pigny, P., Dahia, P. L. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1648608 · Cited by 331 · see citing works

Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse

Kido, M., Du, L., Sullivan, C. C., Li, X., Deutsch, R., Jamieson, S. W., & Thistlethwaite, P. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.045 · Cited by 331 · see citing works

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

Percy, M. J., Zhao, Q., Flores, A., Harrison, C., Lappin, T. R. J., Maxwell, P. H., McMullin, M. F., & Lee, F. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508423103 · Cited by 330 · see citing works

Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress

Salnikow, K., Donald, S. P., Bruick, R. K., Zhitkovich, A., Phang, J. M., & Kasprzak, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403057200 · Cited by 319 · see citing works

Mitochondrial Oxygen Affinity, Respiratory Flux Control And Excess Capacity Of Cytochrome c Oxidase

Gnaiger, E., Lassnig, B., Kuznetsov, A. V., Rieger, G. E., & Margreiter, R. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1129 · Cited by 318 · see citing works

Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor

Vincent, K. A., Shyu, K., Luo, Y., Magner, M., Tio, R. A., Jiang, C., Goldberg, M. A., Akita, G. Y., Gregory, R. J., & Isner, J. M. (2000) · Circulation · doi:10.1161/01.cir.102.18.2255 · Cited by 314 · see citing works

A Gain-of-Function Mutation in the <i>HIF2A</i> Gene in Familial Erythrocytosis

Percy, M. J., Furlow, P. W., Lucas, G. S., Li, X., Lappin, T. R. J., McMullin, M. F., & Lee, F. S. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa073123 · Cited by 314 · see citing works

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313 · see citing works

Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia

Hayashi, T., Abe, K., & Itoyama, Y. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199808000-00009 · Cited by 308 · see citing works

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

Minamishima, Y. A., Moslehi, J., Bardeesy, N., Cullen, D., Bronson, R. T., & Kaelin, W. G. (2008) · Blood · doi:10.1182/blood-2007-10-117812 · Cited by 294 · see citing works

Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure

Bernhardt, W. M., Accent]mpean, V. C. C., Kany, S., Diaeresis]rgensen, J.-S. J., Weidemann, A., Warnecke, C., Arend, M., Klaus, S. J., Diaeresis]nzler, V. G., Amann, K., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121302 · Cited by 294 · see citing works

Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin

Prass, K., Scharff, A., Ruscher, K., Löwl, D., Muselmann, C., Victorov, I. V., Kapinya, K. J., Dirnagl, U., & Meisel, A. (2003) · Stroke · doi:10.1161/01.str.0000080381.76409.b2 · Cited by 285 · see citing works

Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt

Wick, A., Wick, W., Waltenberger, J. L., Weller, M., DICHGANS, J., & Schulz, J. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06401.2002 · Cited by 283 · see citing works

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

Siddiq, A., Ayoub, I. A., Chavez, J. C., Aminova, L. R., Shah, S., LaManna, J. C., Patton, S. M., Connor, J. R., Cherny, R. A., Volitakis, I., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504963200 · Cited by 280 · see citing works

Hypoxia Tolerance in Mammals and Birds: From the Wilderness to the Clinic

Ramirez, J., Folkow, L. P., & Blix, A. S. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.163111 · Cited by 280 · see citing works

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

Hill, P., Shukla, D., Tran, M. G. B., Aragonés, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006090998 · Cited by 280 · see citing works

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

Gordeuk, V. R., Sergueeva, A. I., Miasnikova, G. Y., Okhotin, D., Voloshin, Y., Choyke, P. L., Butman, J. A., Jedlickova, K., Prchal, J. T., & Polyakova, L. A. (2004) · Blood · doi:10.1182/blood-2003-07-2535 · Cited by 273 · see citing works

Hypoxia inducible factor (HIF) function in innate immunity and infection

Zinkernagel, A. S., Johnson, R. S., & Nizet, V. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0282-2 · Cited by 265 · see citing works

The human side of hypoxia‐inducible factor

Smith, T. G., Robbins, P. A., & Ratcliffe, P. J. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07029.x · Cited by 264 · see citing works

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Takeda, K., Aguila, H. L., Parikh, N. S., Li, X., Lamothe, K., Duan, L.-J., Takeda, H., Lee, F. S., & Fong, G.-H. (2008) · Blood · doi:10.1182/blood-2007-09-114561 · Cited by 263 · see citing works

Inhibition of Toll-like Receptor and Cytokine Signaling—A Unifying Theme in Ischemic Tolerance

Karikó, K., Weissman, D., & Welsh, F. A. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000145666.68576.71 · Cited by 260 · see citing works

Induction of Renoprotective Gene Expression by Cobalt Ameliorates Ischemic Injury of the Kidney in Rats

Matsumoto, M., Makino, Y., Tanaka, T., Tanaka, H., Ishizaka, N., Noiri, E., Fujita, T., & Nangaku, M. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000074239.22357.06 · Cited by 256 · see citing works

Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury

Leonard, M. O., Kieran, N. E., Howell, K. B., Burne, M. J., Varadarajan, R., Dhakshinamoorthy, S., Porter, A. G., O’Farrelly, C., Rabb, H., & Taylor, C. T. (2006) · The FASEB Journal · doi:10.1096/fj.06-5097fje · Cited by 255 · see citing works

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

Obrenovitch, T. P. (2008) · Physiological Reviews · doi:10.1152/physrev.00039.2006 · Cited by 250 · see citing works

Hypoxic preconditioning protects against ischemic brain injury

Sharp, F. R., Ran, R., Lu, A., Tang, Y., Strauss, K. I., Glass, T. F., Ardizzone, T. D., & Bernaudin, M. (2004) · NeuroRx · doi:10.1602/neurorx.1.1.26 · Cited by 244 · see citing works

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1

Cai, Z., Zhong, H., Bosch‐Marcé, M., Fox-Talbot, K., Wang, L., Wei, C., Trush, M. A., & Semenza, G. L. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm035 · Cited by 244 · see citing works

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

Takeda, K., Cowan, A., & Fong, G.-H. (2007) · Circulation · doi:10.1161/circulationaha.107.701516 · Cited by 236 · see citing works

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Ehrismann, D., Flashman, E., Genn, D. N., Mathioudakis, N., Hewitson, K. S., Ratcliffe, P. J., & Schofield, C. J. (2007) · Biochemical Journal · doi:10.1042/bj20061151 · Cited by 225 · see citing works

Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

Jones, N. M., & Bergeron, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00008 · Cited by 222 · see citing works

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

Hirsilä, M., Koivunen, P., Xu, L., Seeley, T. W., Kivirikko, K. I., & Myllyharju, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-3399fje · Cited by 220 · see citing works

Oxygen sensors in context

Ward, J. P. T. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.10.010 · Cited by 219 · see citing works

OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J. C., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., & Semenza, G. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.011 · Cited by 218 · see citing works

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

Grenz, A., Oßwald, H., Eckle, T. D. L. G., Yang, D., Zhang, H., Tran, Z. V., Klingel, K., Ravid, K., & Eltzschig, H. K. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050137 · Cited by 216 · see citing works

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

Ockaili, R. A., Natarajan, R., Salloum, F. N., Fisher, B. J., Jones, D. G., Fowler, A. A., & Kukreja, R. C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2005 · Cited by 214 · see citing works

Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway

Dann, C. E., Bruick, R. K., & Deisenhofer, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202614999 · Cited by 200 · see citing works

Myocardial hibernation: a delicate balance

Heusch, G., Schulz, R., & Rahimtoola, S. H. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01109.2004 · Cited by 200 · see citing works

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

Warnecke, C., Griethe, W., Weidemann, A., Jürgensen, J. S., Willam, C., Bachmann, S., Ivashchenko, Y., Wagner, I., Frei, U. A., Wiesener, M., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1062fje · Cited by 199 · see citing works

Inducible Nitric-oxide Synthase Is an Important Contributor to Prolonged Protective Effects of Ischemic Preconditioning in the Mouse Kidney

Park, K. M., Byun, J.-Y., Kramers, C., Kim, J. I., Huang, P. L., & Bonventre, J. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301778200 · Cited by 198 · see citing works

Oxygen, the Lead Actor in the Pathophysiologic Drama: Enactment of the Trinity of Normoxia, Hypoxia, and Hyperoxia in Disease and Therapy

Kulkarni, A. C., Kuppusamy, P., & Parinandi, N. L. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1724 · Cited by 189 · see citing works

Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat

Shyu, K.-G., Wang, M.-T., Wang, B., Chang, C.-C., Leu, J.-G., Kuan, P., & Chang, H. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00259-6 · Cited by 185 · see citing works

Hibernating Myocardium

Heusch, G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1055 · Cited by 182 · see citing works

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase

Palacios‐Callender, M., Quintero, M., Hollis, V., Springett, R., & Moncada, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401723101 · Cited by 181 · see citing works

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice

Bishop, T., Gallagher, D., Pascual, A., Lygate, C. A., de Bono, J. P., Nicholls, L. G., Ortega‐Sáenz, P., Oster, H., Wijeyekoon, B., Sutherland, A., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02041-07 · Cited by 181 · see citing works

Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

Thiel, M., Caldwell, C. C., Kreth, S., Kuboki, S., Chen, P., Smith, P., Ohta, A., Lentsch, A. B., Lukashev, D., & Sitkovsky, M. V. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000853 · Cited by 175 · see citing works

Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal

Andrews, M. T., Squire, T. L., Bowen, C. M., & Rollins, M. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8392 · Cited by 165 · see citing works

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice

Milkiewicz, M., Pugh, C. W., & Egginton, S. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.069757 · Cited by 165 · see citing works

Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal

Buck, M. J., Squire, T. L., & Andrews, M. T. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00076.2001 · Cited by 164 · see citing works

The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)

Ozer, A., Wu, L. C., & Bruick, R. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502716102 · Cited by 161 · see citing works

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

Nishi, K., Oda, T., Takabuchi, S., Oda, S., Fukuda, K., Adachi, T., Semenza, G. L., Shingu, K., & Hirota, K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1825 · Cited by 156 · see citing works

Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes

Stolze, I. P., Tian, Y.-M., Appelhoff, R. J., Turley, H., Wykoff, C. C., Gleadle, J., & Ratcliffe, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406713200 · Cited by 155 · see citing works

Protective Role of Ecto-5′-Nucleotidase (CD73) in Renal Ischemia

Grenz, A., Zhang, H., Eckle, T. D. L. G., Mittelbronn, M. G. A., Wehrmann, M., Köhle, C., Kloor, D., Thompson, L. F., Oßwald, H., & Eltzschig, H. K. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006101141 · Cited by 155 · see citing works

Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor

McDonough, M. A., McNeill, L. A., Tilliet, M., Papamicaël, C. A., Chen, Q., Banerji, B., Hewitson, K. S., & Schofield, C. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050841b · Cited by 149 · see citing works

Hibernation, a Model of Neuroprotection

Zhou, F., Zhu, X., Castellani, R. J., Stimmelmayr, R., Perry, G. L., Smith, M. A., & Drew, K. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64686-x · Cited by 146 · see citing works

2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

Mole, D. R., Schlemminger, I., McNeill, L. A., Hewitson, K. S., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Bioorganic &amp; Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00539-0 · Cited by 145 · see citing works

Novel Mechanism of Action for Hydralazine

Knowles, H. J., Tian, Y., Mole, D. R., & Harris, A. L. (2004) · Circulation Research · doi:10.1161/01.res.0000134924.89412.70 · Cited by 143 · see citing works

Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores

Hartmann, H., Eltzschig, H. K., Wurz, H., Hantke, K., Rakin, A., Yazdi, A. S., Matteoli, G., Bohn, E., Autenrieth, I. B., Karhausen, J., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.008 · Cited by 143 · see citing works

Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase.

Majamaa, K., Günzler, V., Hanauske-Abel, H. M., Myllylä, R., & Kivirikko, K. I. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57475-0 · Cited by 135 · see citing works

Neuroprotection of Ischemic Brain by Vascular Endothelial Growth Factor is Critically Dependent on Proper Dosage and May Be Compromised by Angiogenesis

Manoonkitiwongsa, P. S., Schultz, R. L., McCreery, D. B., Whitter, E. F., & Lyden, P. D. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000126236.54306.21 · Cited by 131 · see citing works

Inhibition of Collagen Synthesis With Prolyl 4-Hydroxylase Inhibitor Improves Left Ventricular Function and Alters the Pattern of Left Ventricular Dilatation After Myocardial Infarction

Nwogu, J. I., Geenen, D., Bean, M., Brenner, M. C., Huang, X., & Buttrick, P. M. (2001) · Circulation · doi:10.1161/hc4301.097193 · Cited by 131 · see citing works

Program of Cell Survival Underlying Human and Experimental Hibernating Myocardium

Depré, C., Kim, S., John, A. S., Huang, Y., Rimoldi, O. E., Pepper, J., Dreyfus, G., Gaussin, V., Pennell, D. J., Vatner, D. E., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000138301.42713.18 · Cited by 130 · see citing works

HIF-1–Dependent Respiratory, Cardiovascular, and Redox Responses to Chronic Intermittent Hypoxia

Semenza, G. L., & Prabhakar, N. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1691 · Cited by 129 · see citing works

Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation

May, D., Gilon, D., Djonov, V., Itin, A., Lazarus, A., Gordon, O. M., Rosenberger, C., & Keshet, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707778105 · Cited by 127 · see citing works

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat

Fréret, T., Valable, S., Chazalviel, L., Saulnier, R., MacKenzie, E. T., Petit, E., Bernaudin, M., Boulouard, M., & Schumann‐Bard, P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04699.x · Cited by 125 · see citing works

Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau

Lee, C., Kim, S. J., Jeong, D. G., Lee, S. M., & Ryu, S. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210385200 · Cited by 121 · see citing works

PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?

Mocanu, M. M., & Yellon, D. M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707155 · Cited by 120 · see citing works

Regional manifestations and control of the immune system

Saadi, S., Wrenshall, L. E., & Platt, J. L. (2002) · The FASEB Journal · doi:10.1096/fj.01-0690hyp · Cited by 119 · see citing works

Hypoxia tolerance in mammalian heterotherms

Drew, K. L., Harris, M. B., LaManna, J. C., Smith, M. A., Zhu, X. W., & Ma, Y. L. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01114 · Cited by 115 · see citing works

Ischemic Pre-conditioning in Deceased Donor Liver Transplantation: A Prospective Randomized Clinical Trial

Amador, A., Grande, L., Martí, J. M., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01914.x · Cited by 112 · see citing works

Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest

Fallavollita, J. A., Malm, B. J., & Canty, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000049104.57549.03 · Cited by 111 · see citing works

A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia

Nangaku, M., Izuhara, Y., Takizawa, S., Yamashita, T., Fujii‐Kuriyama, Y., Ohneda, O., Yamamoto, M. P., de Strihou, C. V. Y., Hirayama, N., & Miyata, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.148551 · Cited by 110 · see citing works

PTEN Activity Is Modulated During Ischemia and Reperfusion

Cai, Z. P., & Semenza, G. L. (2005) · Circulation Research · doi:10.1161/01.res.0000195656.52760.30 · Cited by 108 · see citing works

A role for hypoxia-inducible factor-1α in desferoxamine neuroprotection

Hamrick, S. E. G., McQuillen, P. S., Jiang, X., Mu, D., Madan, A., & Ferriero, D. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.080 · Cited by 106 · see citing works

Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation

Quintero, M., Brennan, P. A., Thomas, G. J., & Moncada, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0333 · Cited by 106 · see citing works

Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Willam, C., Masson, N., Tian, Y., Mahmood, S., Wilson, M. I., Bicknell, R., Eckardt, K., Maxwell, P. H., Ratcliffe, P. J., & Pugh, C. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162119399 · Cited by 104 · see citing works

The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability

Barth, S., Nesper, J., Hasgall, P. A., Wirthner, R., Nytko, K. J., Edlich, F., Katschinski, D. M., Stiehl, D. P., Wenger, R. H., & Camenisch, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01324-06 · Cited by 103 · see citing works

The antimycotic ciclopirox olamine induces HIF‐1α stability, VEGF expression, and angiogenesis

Linden, T., Katschinski, D. M., Eckhardt, K., Scheid, A., Pagel, H., & Wenger, R. H. (2003) · The FASEB Journal · doi:10.1096/fj.02-0586fje · Cited by 102 · see citing works

Ischemic Preconditioning: From Molecular Mechanisms to Therapeutic Opportunities

Otani, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1679 · Cited by 101 · see citing works

Persistent Stunning Induces Myocardial Hibernation and Protection

Kim, S., Peppas, A. P., Hong, S.-K., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000076892.18394.b6 · Cited by 100 · see citing works

Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury

Date, T., Mochizuki, S., Belanger, A. J., Yamakawa, M., Luo, Z., Vincent, K. A., Cheng, S. H., Gregory, R. J., & Jiang, C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00374.2004 · Cited by 98 · see citing works

Long-Term Tolerance to Retinal Ischemia by Repetitive Hypoxic Preconditioning: Role of HIF-1α and Heme Oxygenase-1

Zhu, Y., Zhang, Y., Ojwang, B., Brantley, M. A., & Gidday, J. M. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1037 · Cited by 93 · see citing works

LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner

西, 憲. (2008) · Medical Entomology and Zoology · Cited by 93 · see citing works

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

Rosenberger, C., Rosen, S., Shina, A., Frei, U. A., Eckardt, K., Flippin, L. A., Arend, M., Klaus, S. J., & Heyman, S. N. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn276 · Cited by 90 · see citing works

Adeno-Associated Viral Vector-Mediated Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury After Focal Cerebral Ischemia in Mice

Shen, F., Su, H., Fan, Y., Chen, Y., Zhu, Y., Liu, W., Young, W. L., & Yang, G. (2006) · Stroke · doi:10.1161/01.str.0000240407.14765.e8 · Cited by 88 · see citing works

Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine With Chronic Hibernating Myocardium

Page, B. J., Young, R. F., Iyer, V., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.155895 · Cited by 87 · see citing works

Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action.

Sasaki, T., Majamaa, K., & Uitto, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48093-3 · Cited by 86 · see citing works

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion

Zhong, Z., Ramshesh, V. K., Rehman, H., Currin, R. T., Sridharan, V., Theruvath, T. P., Kim, I., Wright, G. L., & Lemasters, J. J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90287.2008 · Cited by 84 · see citing works

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

Walmsley, S. R., Cowburn, A. S., Clatworthy, M. R., Morrell, N. W., Roper, E. C., Singleton, V., Maxwell, P. H., Whyte, M. K. B., & Chilvers, E. R. (2006) · Blood · doi:10.1182/blood-2006-04-018796 · Cited by 79 · see citing works

The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain

Sarco, D. P., Becker, J. U., Palmer, C., Sheldon, R. A., & Ferriero, D. M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00878-8 · Cited by 78 · see citing works

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

Baader, E., Tschank, G., Baringhaus, K. H., Burghard, H., & Günzler, V. (1994) · Biochemical Journal · doi:10.1042/bj3000525 · Cited by 78 · see citing works

EPAS1 Promotes Adipose Differentiation in 3T3-L1 Cells

Shimba, S., Wada, T., Hara, S., & Tezuka, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400840200 · Cited by 77 · see citing works

Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

Peng, Z., Ren, P., Kang, Z., Du, J., Lian, Q.-L., Liu, Y., Zhang, J. H., & Sun, X. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.027 · Cited by 76 · see citing works

The Novel WD-repeat Protein Morg1 Acts as a Molecular Scaffold for Hypoxia-inducible Factor Prolyl Hydroxylase 3 (PHD3)

Hopfer, U., Hopfer, H., Jablonski, K., Stahl, R. A. K., & Wolf, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513751200 · Cited by 74 · see citing works

Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors

Warshakoon, N. C., Wu, S., Boyer, A. S., Kawamoto, R. M., Renock, S., Xu, K., Pokross, M. E., Evdokimov, A. G., Zhou, S., Winter, C., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.017 · Cited by 74 · see citing works

Attenuation of reperfusion injury by renal ischaemic preconditioning: the role of nitric oxide

Jefayri, M. K., Grace, P. A., & Mathie, R. T. (2000) · British Journal of Urology · doi:10.1046/j.1464-410x.2000.00678.x · Cited by 74 · see citing works

Selective pathological changes of the periaqueductal gray matter in Alzheimer's disease

Parvizi, J., Hoesen, G. W. V., & Damásio, A. R. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 70 · see citing works

Early Stress Protein Gene Expression in a Human Model of Ischemic Preconditioning

Patel, A., van de Poll, M. C. G., Greve, J. W. M., Buurman, W. A., Fearon, K. C. H., McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., Dejong, C. H. C., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000144182.27897.1e · Cited by 69 · see citing works

Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals

Dendorfer, A., Heidbreder, M., Hellwig-Bürgel, T., Jöhren, O., Qadri, F., & Dominiak, P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.015 · Cited by 68 · see citing works

Genes controlling the metabolic switch in hibernating mammals

Andrews, M. T. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321021 · Cited by 66 · see citing works

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

Schlemminger, I., Mole, D. R., McNeill, L. A., Dhanda, A., Hewitson, K. S., Tian, Y., Ratcliffe, P. J., Pugh, C. W., & Schofield, C. J. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00149-5 · Cited by 66 · see citing works

Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack

Malhotra, S., Savitz, S. I., Ocava, L., et al. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20705 · Cited by 64 · see citing works

Renin Gene Transfer Restores Angiogenesis and Vascular Endothelial Growth Factor Expression in Dahl S Rats

Amaral, S. L., Roman, R. J., & Greene, A. S. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.386 · Cited by 64 · see citing works

Oxygen, Hypoxia, and Stress

Taylor, C. T., & Pouysségur, J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1391.004 · Cited by 64 · see citing works

Modulating the Hypoxia-Inducible Factor Signaling Pathway: Applications From Cardiovascular Disease to Cancer

Hewitson, K. S., McNeill, L. A., & Schofield, C. J. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452884 · Cited by 64 · see citing works

Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries.

McCaffrey, T. A., Pomerantz, K. B., Sanborn, T. A., Spokojny, A. M., Du, B., Park, M. H., Folk, J. E., Lamberg, A., Kivirikko, K. I., & Falcone, D. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117684 · Cited by 58 · see citing works

Structure of factor-inhibiting hypoxia-inducible factor 1 : An asparaginyl hydroxylase involved in the hypoxic response pathway

Dann (2002) · Medical Entomology and Zoology · Cited by 58 · see citing works

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors

Warshakoon, N. C., Wu, S., Boyer, A. S., Kawamoto, R. M., Sheville, J., Renock, S., Xu, K., Pokross, M. E., Zhou, S., Winter, C., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.040 · Cited by 56 · see citing works

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS

Philipp, S., Cui, L., Ludolph, B., Kelm, M., Schulz, R., Cohen, M. V., & Downey, J. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00472.2005 · Cited by 54 · see citing works

Hypoxic tolerance in air-breathing invertebrates

Schmitz, A., & Harrison, J. F. (2004) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2003.12.004 · Cited by 53 · see citing works

Modulation of Leukocyte Behavior by an InflamedExtracellular Matrix

Schor, H., Vaday, G. G., & Lider, O. (2000) · Journal of Immunology Research · doi:10.1155/2000/51902 · Cited by 53 · see citing works

The role of dietary fatty acids in the evolution of spontaneous and facultative hibernation patterns in prairie dogs

Harlow, H. J., & Frank, C. L. (2001) · Journal of Comparative Physiology B · doi:10.1007/s003600000148 · Cited by 52 · see citing works

Adenosine‐dependent activation of hypoxia‐inducible factor‐1 induces late preconditioning in liver cells†

Alchera, E., Tacchini, L., Imarisio, C., Ponte, C. D., Ponti, C. D., Gammella, E., Cairo, G., Albano, E., & Carini, R. (2008) · Hepatology · doi:10.1002/hep.22249 · Cited by 50 · see citing works

Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes

Wright, G. L., Higgin, J. J., Raines, R. T., Steenbergen, C., & Murphy, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301391200 · Cited by 49 · see citing works

Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts1Previously published in abstract form: Circulation 94(8) (1996) I 355.1

Ju, H., Hao, J., Zhao, S., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00114-1 · Cited by 48 · see citing works

Seasonal changes in serum lipids and proteins in the 13-lined ground squirrel

Galster, W. A., & MORRISON, P. R. (1966) · Comparative Biochemistry and Physiology · doi:10.1016/0010-406x(66)90233-7 · Cited by 47 · see citing works

Prolyl Hydroxylase Domain 2 Protein Suppresses Hypoxia-Induced Endothelial Cell Proliferation

Takeda, K., & Fong, G. (2006) · Hypertension · doi:10.1161/01.hyp.0000251360.40838.0f · Cited by 47 · see citing works

Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains

Villar, D., Vara-Vega, A., Landázuri, M. O., & del Peso, L. (2007) · Biochemical Journal · doi:10.1042/bj20071052 · Cited by 39 · see citing works

Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions

Floyd, Z. E., Kilroy, G. E., Wu, X., & Gimble, J. M. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21266 · Cited by 37 · see citing works

Prolyl‐hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype

Irwin, R., LaPres, J. J., Kinser, S., & McCabe, L. R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21083 · Cited by 37 · see citing works

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

Sridharan, V., Guichard, J. L., Bailey, R. M., Kasiganesan, H., Beeson, C. C., & Wright, G. L. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00100.2006 · Cited by 37 · see citing works

HIF-1α expression in response to lipopolysaccaride mediates induction of hepatic inflammatory cytokine TNFα

Kim, H. Y., Kim, Y. H., Nam, B., Kong, H. J., Kim, H. H., Kim, Y. J., An, W. G., & Cheong, J. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.009 · Cited by 36 · see citing works

Transcriptional Regulation of the Hypoxia Inducible Factor-2.ALPHA. (HIF-2.ALPHA.) Gene during Adipose Differentiation in 3T3-L1 Cells

Wada, T., Shimba, S., & Tezuka, M. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.49 · Cited by 31 · see citing works

Characteristics of Renal Tubular Atrophy in Experimental Renovascular Hypertension: A Model of Kidney Hibernation

Gröne, H. J., Warnecke, E., & Olbricht, C. J. (2008) · ˜The œNephron journals/Nephron journals · doi:10.1159/000188849 · Cited by 23 · see citing works

Mitochondrial Dysfunction via Disruption of Complex II Activity during Iron Chelation—Induced Senescence‐like Growth Arrest of Chang Cells

Yoon, Y., Cho, H., Lee, J., & Yoon, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1293.013 · Cited by 21 · see citing works

Inhibition of Prolyl Hydroxylation During Collagen Biosynthesis in Human Skin Fibroblast Cultures by Ethyl 3,4-Dihydroxybenzoate

Majamaa, K., Sasaki, T., & Uitto, J. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12471775 · Cited by 20 · see citing works

Hypoxic reprogramming

Kelly, D. P. (2008) · Nature Genetics · doi:10.1038/ng0208-132 · Cited by 18 · see citing works

Metabolic changes in hibernating myocardium after percutaneous transluminal coronary angioplasty and the relation between recovery in left ventricular function and free fatty acid metabolism

Shimonagata, T., Nanto, S., Kusuoka, H., et al. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00399-3 · Cited by 17 · see citing works

EFFECT OF INDOMETHACIN ON HYDRALAZINE‐INDUCED RENIN AND CATECHOLAMINE RELEASE IN THE CONSCIOUS RABBIT

Campbell, W. B., Graham, R. M., Jackson, E. K., et al. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10968.x · Cited by 13 · see citing works

A hibernating kidney ischemic preconditioning in a renal transplant recipient with a proximal stenosis of the iliac artery

Warncke, J. C., David, S., Kümpers, P., et al. (2008) · Clinical Nephrology · doi:10.5414/cnp70168 · Cited by 12 · see citing works

Antiproliferative and Fibrosuppressive Effects on Smooth Muscle Cells from Human Coronary Arteries

McCaffrey, T. A., Pomerantz, K. B., Sanbom, T. A., Spokojny, A. M., Folk, J. E., Lamberg, A., Falcone, D. J., Mehta, S. B., & Hanauske-Abeill, H. M. (1995) · Cited by 11 · see citing works

Myocardial metabolism of 123I-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and 18F-FDG

Hosokawa, R., Nohara, R., Fujibayashi, Y., et al. (2001) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590100617 · Cited by 7 · see citing works

W1376 Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor

Hartmann, C., Degenkolb, N., Steinkamp, M., Adler, G., & von Boyen, G. B. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)63226-6 · Cited by 5 · see citing works

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061 · see citing works

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264 · see citing works

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195 · see citing works

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560 · see citing works

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Adibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480 · see citing works

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294 · see citing works

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021637 · Cited by 288 · see citing works

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245 · see citing works

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

McNamee, E. N., Korns Johnson, D., Homann, D., & Clambey, E. T. (2013) · Immunologic Research · doi:10.1007/s12026-012-8349-8 · Cited by 234 · see citing works

The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, C. T., & Cummins, E. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05024.x · Cited by 175 · see citing works

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Madsen, C. D., Pedersen, J. T., Venning, F. A., Singh, L. B., Moeendarbary, E., Charras, G., Cox, T. R., Sahai, E., & Erler, J. T. (2015) · The EMBO Reports · doi:10.15252/embr.201540107 · Cited by 157 · see citing works

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

Taylor, C. T., & McElwain, J. C. (2010) · Physiology · doi:10.1152/physiol.00029.2010 · Cited by 135 · see citing works

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1978-z · Cited by 99 · see citing works

Ischemic preconditioning attenuates ischemia/reperfusion-induced kidney injury by activating autophagy via the SGK1 signaling pathway

Xie, Y., Jiang, D., Xiao, J., Fu, C., Zhang, Z., Ye, Z., & Zhang, X. (2018) · Cell Death &amp; Disease · doi:10.1038/s41419-018-0358-7 · Cited by 73 · see citing works

Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance

Matsuura, H., Ichiki, T., Inoue, E., Nomura, M., Miyazaki, R., Hashimoto, T., Ikeda, J., Takayanagi, R., Fong, G.-H., & Sunagawa, K. (2013) · Circulation · doi:10.1161/circulationaha.113.001742 · Cited by 77 · see citing works

Hydroxylase Inhibition Abrogates TNF-α–Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1–Dependent Repression of FADD

Hindryckx, P., De Vos, M., Jacques, P., Ferdinande, L., Peeters, H., Olievier, K., Bogaert, S., Brinkman, B., Vandenabeele, P., Elewaut, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002541 · Cited by 73 · see citing works

IGF binding protein‐6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis

Zhang, C., Lu, L., Li, Y., Wang, X., Zhou, J., Liu, Y., Fu, P., Gallicchio, M. A., Bach, L. A., & Duan, C. (2012) · International Journal of Cancer · doi:10.1002/ijc.26201 · Cited by 67 · see citing works

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

Laitala, A., Aro, E., Walkinshaw, G., Mäki, J. M., Rossi, M., Heikkilä, M., Savolainen, E.-R., Arend, M., Kivirikko, K. I., Koivunen, P., et al. (2012) · Blood · doi:10.1182/blood-2012-07-441824 · Cited by 58 · see citing works

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

Labiano, S., Meléndez-Rodríguez, F., Palazón, A., Teijeira, Á., Garasa, S., Etxeberria, I., Aznar, M. Á., Sánchez-Paulete, A. R., Azpilikueta, A., Bolaños, E., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1283468 · Cited by 35 · see citing works

A Multi‐Bioactive Nanomicelle‐Based “One Stone for Multiple Birds” Strategy for Precision Therapy of Abdominal Aortic Aneurysms

Lin, W., Hu, K., Li, C., Pu, W., Yan, X., Chen, H., Hu, H., Deng, H., & Zhang, J. (2022) · Advanced Materials · doi:10.1002/adma.202204455 · Cited by 33 · see citing works

EPH74 Mortality From Ischaemic Heart Disease Among Women in Hungary by County

Németh, N., Endrei, D., Horváth, L., et al. (2022) · Value in Health · doi:10.1016/j.jval.2022.09.996

Importance of investigation of myocardial metabolites in diagnosis and evaluation of treatment of ischaemic heart disease.

Fabian, J., Brodan, V., Spáčil, J., et al. (1984) · PubMed

Interaction between reactive oxygen species and gallocyanine under neutrophil activation

Lutsenko, V. E., Grigorieva, D. V., Gorudko, I. V., et al. (2020) · Doklady of the National Academy of Sciences of Belarus · doi:10.29235/1561-8323-2019-63-6-730-735 · Cited by 1 · see citing works

A shortage of dentists is only part of the problem

Campbell, R., & Perry (2005) · Nursing Standard · doi:10.7748/ns.20.9.39.s50

EPH190 Premature Mortality From Ischaemic Heart Disease Among Men in Hungary by District

Németh, N., Boncz, I., Horváth, L., et al. (2022) · Value in Health · doi:10.1016/j.jval.2022.09.1111