The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal
Open accessAbstract
Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved signaling pathways, which includes the Wnt signaling pathway. The DNA-binding proteins of the T-cell factor family, Tcf1/Tcf7, Lef, Tcf3/Tcf7l1, and Tcf4/Tcf7l2, constitute the downstream effectors of the Wnt signaling pathway. While Tcf4 is the major member active during embryogenesis, the role of these Wnt effectors in the homeostasis of the adult mouse intestinal epithelium is unresolved. Using Tcf1-/-, Tcf3(flox), and novel Tcf4(flox) mice, we demonstrate an essential role for Tcf4 during homeostasis of the adult mouse intestine.
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Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Self-citationIdentification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Self-citationPaneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287
Cited by
The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Self-citationThe R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes & Development · doi:10.1101/gad.235473.113 · Cited by 656
Self-citationReg4 + deep crypt secretory cells function as epithelial niche for Lgr5 + stem cells in colon
Sasaki, N., Sachs, N., Wiebrands, K., Ellenbroek, S. I. J., Fumagalli, A., Lyubimova, A., Begthel, H., van den Born, M., van Es, J. H., Karthaus, W. R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607327113 · Cited by 314
Self-citationAscl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
Schuijers, J., Junker, J. P., Mokry, M., Hatzis, P., Koo, B.-K., Sasselli, V., van der Flier, L. G., Cuppen, E., van Oudenaarden, A., & Clevers, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.006 · Cited by 273
Self-citationOpposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis
Tian, H., Biehs, B., Chiu, C., Siebel, C. W., Wu, Y., Costa, M., de Sauvage, F. J., & Klein, O. D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.007 · Cited by 214
Metadata
- Authors
- van Es, J. H., Haegebarth, A., Kujala, P., Itzkovitz, S., Koo, B.-K., Boj, S. F., Korving, J., van den Born, M., van Oudenaarden, A., Robine, S., & Clevers, H.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2012-05-01
- Volume
- 32
- Issue
- 10
- Pages
- 1918-1927
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2143625921
- Cited by
- 276
- References
- 4
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- green
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- van Es, J. H., Haegebarth, A., Kujala, P., Itzkovitz, S., Koo, B.-K., Boj, S. F., Korving, J., van den Born, M., van Oudenaarden, A., Robine, S., & Clevers, H. (2012). A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.06288-11
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